Hyperpigmentation of the tongue, palms and soles: Rare side effect of capecitabine

Abstract

Cutaneous side effects of capecitabine include hand foot syndrome which manifests as erythema, swelling and/or desquamation. We report a case on capecitabine treatment presenting with unusual hyperpigmentation of the tongue and skin of the palms and soles. This is a rare manifestation of capecitabine toxicity in darker skin patients. Clinicians and health care workers in oncology should be aware of this potential side effect.