A PROSPECTIVE STUDY TO COMPARE CONVENTIONAL CHEMORADIOTHERAPY WITH CONCOMITANT BOOST CHEMORADIOTHERAPY IN CARCINOMA OF ORAL CAVITY

Abstract

Background : India accounts for the highest incidence of lip and oral  cancer in the world. In early stages,surgery and radiation therapy are curative treatments,while locally a locally advanced carcinoma requires a multidisciplinary  management. A major cause of failure in advanced rapidly growing tumors is accelerated repopulation.To overcome this problem ,various accelerated fractionation radiotherapy techniques are used. Aim : To compare the outcome,feasibility,tolerability of concomitant boost chemoradiotherapy over conventional chemoradiotherapy Materials and methods: From November 2018 to June 2020,64 patients from J.K.Cancer institute,Kanpur were enrolled in this study.prospective comparative study was done to find out the difference in all groups Results : out of 59 eligible patients,31 were assigned to arm A(conventional chemoradiation) and 28 were assigned to arm B (concomitant boost chemoradiation). Out of 31 patients in arm A, 15(48.4%) had complete response(CR),8 (25.8%) had partial response (PR),4(12.9%) had stable disease (SD) and 4(12.9%) had progressive disease (PD).In arm B ,out of 28 patients,14(50%) had complete response,6(21.4%) had partial response,6(21.4%) had stable disease and 2 (7.1%) had progressive disease. Conclusion : Concomitant boost chemoradiotherapy had a response comparable to conventional chemoradiotherapy with  moderate efficacy and acceptable toxicity.It can be used as alternative to conventional chemoradiotherapy in limited resource setting where the total duration can be minimized and workload can be reduced. Keywords : oral cavity,concomitant boost technique,conventional chemoradiotherapy.