The Importance of Analytical Chemistry in Therapeutic Drug Monitoring for Personalized Medicine

chemistry and materials research Pub Date : 2020-09-01 DOI:10.7176/cmr/12-7-05

H. Sofiyev, Neşet Neşetoğlu, Ibrahim Danış, Cem Kaplan, Merve Arslan, S. Aslan, D. Unal

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Abstract

Personalized therapy (PM) has the potential to adapt treatment with the best response and highest safety to provide better patient care. Key data is drug concentration of biological materials such as plasma and serum.Individual drug therapy means, choice of a drug and its dose regime should fit every individual specifically. Thus efficacy of a drug treatment would improve significantly. When developing an analytical method for (Therapeutic drug monitoring) TDM, it is important to choose a clinically relevant calibration range. This quantitation range should be built around the proposed target concentration, covering majority of samples as seen in the clinic (Ciocan-Cartita et al. 2019).Inter-individual variability in Pharmacokinetic variables may affect the blood concentration of drug so TDM approaches could solve the dosing problem.To achieve individual drug therapy with a reasonably predictive outcome, one must further account for different patterns of drug response among geographically and ethnically distinct populations. Keywords: LC-MS/MS, Therapeutic Drug Monitoring, Lenalidomide, Anastrozole DOI: 10.7176/CMR/12-7-05 Publication date: September 30 th 2020

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分析化学在个体化治疗药物监测中的重要性

个性化治疗(PM)具有适应治疗的潜力，具有最佳的反应和最高的安全性，以提供更好的患者护理。关键数据是血浆和血清等生物材料的药物浓度。个体化药物治疗意味着，药物的选择及其剂量方案应具体适合每个人。因此，药物治疗的疗效将显著提高。在开发TDM(治疗药物监测)分析方法时，选择与临床相关的校准范围非常重要。该定量范围应围绕拟议的目标浓度建立，涵盖临床中看到的大多数样品(Ciocan-Cartita et al. 2019)。药代动力学变量的个体差异可能影响药物的血药浓度，因此TDM方法可以解决给药问题。为了实现具有合理预测结果的个体化药物治疗，必须进一步考虑在地理和种族上不同的人群中药物反应的不同模式。关键词:LC-MS/MS，治疗药物监测，来那度胺，阿那曲唑DOI: 10.7176/CMR/12-7-05出版日期:2020年9月30日

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chemistry and materials research

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