A PRELIMINARY STUDY OF THE EFFECT OF ANESTHETIC AGENTS ON THE RHEOLOGICAL PARAMETERS OF GLYCATED ERYTHROCYTES

IF 0.1 Q4 PHYSICS, MULTIDISCIPLINARY

Anales AFA Pub Date : 2021-01-15 DOI:10.31527/ANALESAFA.2020.31.4.117

M. V. B. D. Silva, Facultad Cs. Bioquímicas y Farmacéuticas Rosario Argentina. Área Física, H. Castellini, N. Alet, B. Riquelme, Analía I. Alet, Fceia – Rosario Argentina Departamento de Física, Argentina. Facultad de Cs. Médicas Rosario, Ifir Rosario Argentina. Grupo de Óptica Aplicada a la Biología

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引用次数: 1

Abstract

This paper presents a preliminary study of the effects of the anesthetics propofol, remifentanil, and vecuronium bromide on the rheological properties of glycated erythrocytes in vitro, modeling the glycation by hyperglycemia observed in diabetes. Viscoelastic and aggregation kinetic parameters of erythrocytes were determined using an erythrocyte rheometer and an optical chip aggregometer developed in our laboratory. The results showed significant alterations in the membrane surface viscosity, the elastic modulus, and the erythrocyte deformability index for the different anesthetics studied. Also, the kinetics aggregation parameters showed different types of alterations due to the effect of anesthetics. This preliminary study suggests that the use of these anesthetics in diabetic patients could induce hemorheological alterations that disturb the microcirculation. For this reason, it is recommended to deepen these investigations to prevent complications in surgical procedures.

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麻醉药物对糖化红细胞流变学参数影响的初步研究

本文初步研究了异丙酚、瑞芬太尼和维库溴铵对体外糖基化红细胞流变学特性的影响，模拟了糖尿病患者高血糖引起的糖基化。用本实验室研制的红细胞流变仪和光学芯片聚集仪测定红细胞的粘弹性和聚集动力学参数。结果表明，不同麻醉药对细胞膜表面黏度、弹性模量和红细胞变形指数有显著影响。此外，由于麻醉剂的作用，动力学聚集参数显示出不同类型的改变。这项初步研究表明，在糖尿病患者中使用这些麻醉剂可能会引起血液流变学改变，扰乱微循环。因此，建议深化这些调查，以防止手术过程中的并发症。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anales AFA PHYSICS, MULTIDISCIPLINARY-

CiteScore

0.40

自引率

0.00%

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