Pregnancy in PCOS Women and their History of Diabetes

Abstract

Objective: Evaluation of the incidence of gestational diabetes in PCOS women treated with metformin before and during early pregnancy and to ascertain their family history of diabetes. Design: Follow-up on all women with PCOS and infertility who received treatment with metformin prior to pregnancy (=index pregnancy) during 10 years. Data on diabetes was retrieved by questionnaire and hospital charts. Main outcome measures: Incidence of gestational diabetes, pregnancy outcome, and fetal size. Results: In 18 % of the women GDM was diagnosed at some stage. The clinical and obstetrical outcome of the women showed no association with family history of diabetes or GDM. No neonatal anthropometric feature was different with respect to family history of diabetes or GDM and no fetal malformations were found. Conclusion: GDM and family history of diabetes seem not to be associated with unfavourable pregnancy outcome in PCOS women.