Circulating Adiponectin and Resistin Levels Are Associated with Adiposity Indices and Physical Fitness in Healthy Adult Males

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-06-23 DOI:10.12659/MSMBR.930322

S. Habib, Mamoona Sultan, Adeena Khan, T. Al-khlaiwi, S. Bashir

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引用次数: 3

Abstract

Background The aim of this study was to assess the correlation of physical fitness scores (PFS) with serum adiponectin, resistin, and adiponectin/resistin ratio (AR ratio) in relation to body adiposity indices in healthy adult males. Material/Methods This cross-sectional study was conducted at the Clinical Physiology Unit, Physiology Department, King Saud University Medical City, King Saud University, Riyadh, from March 2017 to April 2018. We included 125 healthy adult males. Serum samples were obtained after overnight fasting. Analysis was performed for fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), basal insulin, lipid profile, resistin, and adiponectin. Bioimpedance analysis (BIA) was used to assess body composition. Based on ideal body composition, PFS were computed as previously published for all subjects and compared with serum markers. Results There was a positive correlation of adiponectin with PFS (r=.218, p=0.015) and an inverse correlation with obesity degree (OD), OD (r=−.239, p=0.001), body mass index (BMI) (r=−.244, p=0.001), and waist/hip ratio (WHR) WHR (r=−.296, p=0.001). Moreover, it was correlated negatively with basal insulin (r=−.211, p=0.009) and homeostatic insulin resistance model (HOMA-IR) HOMA-IR (r=−.221, p=0.013). Resistin was correlated negatively with PFS (r=−.203, p=0.023), while its correlation with OD, BMI, WHR, and HOMA-IR was not significant. AR ratio was positively correlated with PFS (r=.286, p=0.001) and negatively with OD (r=−.210, p=0.019), BMI (r=−.222, p=0.013), WHR (r=−.308, p=0.001) and basal insulin (r=−.237, p=0.008). In linear regression analysis, the relationship of PFS was significant with adiponectin (r=.218, p=0.015), resistin (r=−.203, p=0.023) and AR ratio (r=.286, p=0.001). ROC curve analysis showed that individually the values of adiponectin and resistin were not significantly correlated with PFS, but they were significant with the combined AR ratio with AUC 64.6% (p=0.029). Conclusions Serum adiponectin was positively correlated and resistin was negatively correlated with physical fitness scores based on healthy body composition with low proportion of body adiposity and a higher proportion of fat-free mass. However, the combined effect of adiponectin/resistin ratio is an even better predictor of physical fitness. Moreover, the adiponectin/resistin ratio is even more highly associated with physical fitness than adiponectin or resistin alone.

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健康成年男性循环脂联素和抵抗素水平与肥胖指数和身体健康相关

本研究的目的是评估健康成年男性体适能评分(PFS)与血清脂联素、抵抗素和脂联素/抵抗素比值(AR比)与体脂指数的相关性。材料/方法本横断面研究于2017年3月至2018年4月在利雅得沙特国王大学医学城沙特国王大学生理学系临床生理单元进行。我们纳入了125名健康成年男性。空腹过夜后采集血清样本。分析空腹血糖(FBG)、糖化血红蛋白(HbA1c)、基础胰岛素、脂质谱、抵抗素和脂联素。采用生物阻抗分析法(BIA)评价体成分。根据理想体成分，计算所有受试者的PFS，并与血清标志物进行比较。结果脂联素与PFS呈正相关(r=。218, p=0.015)，与肥胖程度(OD)呈负相关，OD (r=−。239, p=0.001)，身体质量指数(BMI) (r=−。244, p=0.001)，腰臀比(WHR) WHR (r=−。296年,p = 0.001)。此外，它与基础胰岛素呈负相关(r= -)。211, p=0.009)和稳态胰岛素抵抗模型(HOMA-IR)。221年,p = 0.013)。抵抗素与PFS呈负相关(r= -)。203, p=0.023)，而与OD、BMI、WHR、HOMA-IR相关性不显著。AR率与PFS呈正相关(r=。286, p=0.001)，与OD呈负相关(r= -。210, p=0.019)， BMI (r=−。222, p=0.013)， WHR (r=−。308, p=0.001)和基础胰岛素(r=−。237年,p = 0.008)。在线性回归分析中，PFS与脂联素有显著关系(r=。218, p=0.015)，抵抗素(r=−。203, p=0.023)， AR比(r= 0.023)。286年,p = 0.001)。ROC曲线分析显示，脂联素和抵抗素的单独值与PFS无显著相关，但其联合AR比(AUC为64.6%)显著(p=0.029)。结论血清脂联素与体脂比例低、无脂质量比例高的健康体质评分呈显著正相关，抵抗素呈显著负相关。然而，脂联素/抵抗素比值的综合效应是一个更好的身体健康预测指标。此外，脂联素/抵抗素比单独的脂联素或抵抗素与身体健康的关系更密切。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.