Analysis of risk factors of bad cardiovascular events in maintenance Peritoneal Dialysis (PD) patients

中国中西医结合肾病杂志 Pub Date : 2010-09-15 DOI:10.3760/CMA.J.ISSN.1673-4416.2010.05.013

Lanbo Teng, Ming-Yang Chang, Shuxin Liu

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Abstract

Objectives To investigate the risk factors of bad cardiovascular events in maintenance peritoneal dialysis patients. Methods 44 patients with maintenance peritoneal dialysis. whose therapy time were all more than 3months were enrolled. According to confirmation standards of bad cardiovascular events, we set bad cardiovascular events group(n-20) and no bad cardiovascular events group(n = 24). Age, gender, primary diseases and dialysis time of two groups were recorded. Serum uric acid, hemoglobin, plasma-albumin, total protein, cholesterol, Triglyceride, high density lipoproteins, low density lipoprotein, calcium, phosphorus, calcium-phosphorus product, parathyroid hormone(iPTH) 、25-(OH) D3, alkaline phosphatase, urea nitrogen, creatinine were recorded, too. Results Plasma-albumin, total protein, creatinine and 25-(OH) D3 in bad cardiovascular events group were lower than no bad cardiovascular events group; but age, cholesterol and uric acid in bad cardiovascular events group were higher than no bad cardiovascular events group(p ＜0.05 or p ＜0.01) ;Logistic regression analysis showed that plasma-albumin, cholesterol, low density lipoprotein, uric acid and 25-(OH)D3 were the significant risk factors of bad cardiovascular events in maintenance peritoneal dialysis. Conclusions Cardiovascular events was the most frequent complication in maintenance peritoneal dialysis patients. Dyslipidemia, malnutrition, high blood uric acid and low 25-(OH) D3 were the significant risk factors of bad cardiovascular events in maintenance peritoneal dialysis. Key words: Peritoneal Dialysis; Cardiovascular Diseases; Risk Factors

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维持性腹膜透析(PD)患者不良心血管事件的危险因素分析

目的探讨维持性腹膜透析患者发生不良心血管事件的危险因素。方法维持腹膜透析44例。纳入治疗时间均在3个月以上的患者。根据心血管不良事件的确认标准，我们设置了心血管不良事件组(n-20)和无心血管不良事件组(n = 24)。记录两组患者的年龄、性别、原发病情况及透析时间。同时记录血清尿酸、血红蛋白、血浆白蛋白、总蛋白、胆固醇、甘油三酯、高密度脂蛋白、低密度脂蛋白、钙、磷、钙磷产物、甲状旁腺激素(iPTH)、25-(OH) D3、碱性磷酸酶、尿素氮、肌酐。结果不良心血管事件组血浆白蛋白、总蛋白、肌酐、25-(OH) D3低于无不良心血管事件组;不良心血管事件组患者年龄、胆固醇、尿酸高于无不良心血管事件组(p <0.05或p <0.01);Logistic回归分析显示血浆白蛋白、胆固醇、低密度脂蛋白、尿酸、25-(OH)D3是维持性腹膜透析患者发生不良心血管事件的显著危险因素。结论心血管事件是维持性腹膜透析患者最常见的并发症。血脂异常、营养不良、高血尿酸和低25-(OH) D3是维持性腹膜透析不良心血管事件的重要危险因素。关键词:腹膜透析;心血管疾病;风险因素

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中国中西医结合肾病杂志

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