The dopaminergic system supports flexible and rewarding dyadic motor interactive behaviour in Parkinson's Disease.

IF 3.9 2区医学 Q2 NEUROSCIENCES

Social cognitive and affective neuroscience Pub Date : 2023-02-23 DOI:10.1093/scan/nsac040

Vanessa Era, Matteo Candidi, Rachele Pezzetta, Claudia Pulcini, Sara D'Antonio, Silvia Zabberoni, Antonella Peppe, Alberto Costa, Sara Taglieri, Giovanni Augusto Carlesimo, Salvatore Maria Aglioti

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引用次数: 3

Abstract

Studies indicate that the dopaminergic system (DAS) supports individual flexible behaviour. While flexibility is quintessential to effective dyadic motor interactions, whether DAS mediates adaptations of one's own motor behaviour to that of a partner is not known. Here, we asked patients with Parkinson's Disease (PD) to synchronize their grasping movements with those of a virtual partner in conditions that did (Interactive) or did not (Cued) require to predict and adapt to its actions. PD performed the task during daily antiparkinsonian treatment ('On' condition) or after drug-withdrawal ('Off' condition). A group of healthy individuals also served as control group. In the Interactive condition, PDs performed better and found the interaction more enjoyable when in 'On' than in 'Off' condition. Crucially, PD performance in the 'On' condition did not differ from that of healthy controls. This pattern of results hints at the key role of the DAS in supporting the flexible adaptation of one's own actions to the partner's during motor interactions.

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多巴胺能系统在帕金森病中支持灵活和有益的二元运动相互作用行为。

研究表明，多巴胺能系统支持个体的灵活行为。虽然灵活性是有效的二元运动相互作用的基本要素，但DAS是否介导了自己的运动行为对伴侣的运动行为的适应尚不清楚。在这里，我们要求帕金森氏症(PD)患者在需要(互动)或不需要(提示)预测和适应其动作的条件下，与虚拟伴侣同步抓取动作。PD在日常抗帕金森治疗期间(“开”状态)或停药后(“关”状态)执行任务。另设一组健康个体作为对照组。在互动条件下，pd在“打开”状态下比在“关闭”状态下表现更好，并且发现互动更愉快。至关重要的是，PD在“开启”状态下的表现与健康对照组没有差异。这种结果模式暗示了DAS在运动互动中支持自己的动作灵活适应伴侣的动作方面的关键作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Social cognitive and affective neuroscience 医学-神经科学

CiteScore

6.80

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.