Correlative Study Between Nutritional Status and Remission Outcome in Childhood Acute Lymphoblastic Leukemia in Dr. Soetomo General Hospital Surabaya

Biomolecular and Health Science Journal Pub Date : 2019-06-30 DOI:10.20473/BHSJ.V2I1.12723

Asma' Athifah, Siti Nurul Hidayati, S. Sulistiawati

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引用次数: 5

Abstract

Introduction: The most common malignancy that is diagnosed in children is acute lymphoblastic leukemia. Undernourished children tend to have poorer long term survival. This descriptive analytic study is aimed towards analyzing the correlation between nutritional status at diagnosis and outcomes of induction phase therapy in childhood acute lymphoblastic leukemia at the Department of Pediatrics Dr. Soetomo General Hospital Surabaya in 2014.Methods: A cross-sectional method using the medical records of patients is used in this study. The nutritional statuses of patients are calculated using weight for length/height trough curves of WHO 2006 or CDC 2000.Results: The results show that from 45 children diagnosed with ALL, 53% are of the age ≤ 5 years old, with 58% males and 42% females. 13% of the patients are in the high risk group and 87% are in the standard risk group. Nutritional statuses of patients are 2% of them obese experienced remission after induction phase therapy, 56% normal with 80% of them experienced remission. 40% underweight with 89% of them experienced remission and 11% not experienced remission, 2% malnutrition and experienced remission. There is no correlation between the nutritional status of children with acute lymphoblastic leukemia with the outcome of induction phase (p = 0.798).Conclusion: In conclusion, there is no correlation between nutritional status and remission outcome of patients with ALL in the induction phase of therapy. However, high percentage of underweight patients shows nutrition needs special attention to improve therapy outcomes.

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泗水Soetomo总医院儿童急性淋巴细胞白血病营养状况与缓解结果的相关性研究

儿童最常见的恶性肿瘤是急性淋巴细胞白血病。营养不良儿童的长期存活率往往较低。本描述性分析研究旨在分析2014年泗水Soetomo综合医院儿科诊断时营养状况与儿童急性淋巴细胞白血病诱导期治疗结果的相关性。方法:本研究采用横断面法，利用患者的医疗记录。患者的营养状况是根据WHO 2006年或CDC 2000年的体重/身高曲线计算的。结果:45例ALL患儿中，年龄≤5岁的占53%，其中男性占58%，女性占42%。13%的患者属于高危组，87%的患者属于标准危险组。患者营养状况:诱导期治疗后肥胖患者缓解率为2%，正常患者56%，缓解率为80%。40%的人体重过轻，89%的人缓解，11%的人没有缓解，2%的人营养不良，也有缓解。急性淋巴细胞白血病患儿营养状况与诱导期结局无相关性(p = 0.798)。结论:综上所述，ALL患者在治疗诱导期的营养状况与缓解结果无相关性。然而，高比例的体重不足患者需要特别注意营养以改善治疗效果。

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Biomolecular and Health Science Journal

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