Activation of the left medial temporal gyrus and adjacent brain areas during affective theory of mind processing correlates with trait schizotypy in a nonclinical population.

IF 3.9 2区医学 Q2 NEUROSCIENCES

Social cognitive and affective neuroscience Pub Date : 2023-02-23 DOI:10.1093/scan/nsac051

Ksenija Vucurovic, Delphine Raucher-Chéné, Alexandre Obert, Pamela Gobin, Audrey Henry, Sarah Barrière, Martina Traykova, Fabien Gierski, Christophe Portefaix, Stéphanie Caillies, Arthur Kaladjian

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引用次数: 1

Abstract

Schizophrenia, a severe psychiatric disorder, is associated with abnormal brain activation during theory of mind (ToM) processing. Researchers recently suggested that there is a continuum running from subclinical schizotypal personality traits to fully expressed schizophrenia symptoms. Nevertheless, it remains unclear whether schizotypal personality traits in a nonclinical population are associated with atypical brain activation during ToM tasks. Our aim was to investigate correlations between fMRI brain activation during affective ToM (ToMA) and cognitive ToM (ToMC) tasks and scores on the Schizotypal Personality Questionnaire (SPQ) and the Basic Empathy Scale in 39 healthy individuals. The total SPQ score positively correlated with brain activation during ToMA processing in clusters extending from the left medial temporal gyrus (MTG), lingual gyrus and fusiform gyrus to the parahippocampal gyrus (Brodmann area: 19). During ToMA processing, the right inferior occipital gyrus, right MTG, precuneus and posterior cingulate cortex negatively correlated with the emotional disconnection subscore and the total score of self-reported empathy. These posterior brain regions are known to be involved in memory and language, as well as in creative reasoning, in nonclinical individuals. Our findings highlight changes in brain processing associated with trait schizotypy in nonclinical individuals during ToMA but not ToMC processing.

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在非临床人群中，情感心理理论加工过程中左内侧颞回和邻近脑区的激活与特质性分裂型相关。

精神分裂症是一种严重的精神疾病，与心理理论(ToM)加工过程中的异常大脑激活有关。研究人员最近提出，从亚临床分裂型人格特征到完全表达的精神分裂症症状，存在一个连续体。然而，目前尚不清楚非临床人群中的分裂型人格特征是否与ToM任务中的非典型脑激活有关。我们的目的是研究39名健康个体在情感性ToM (ToMA)和认知性ToM (ToMC)任务中fMRI脑激活与分裂型人格问卷(SPQ)和基本共情量表得分之间的相关性。从左内侧颞回(MTG)、舌回、梭状回到海马旁回(Brodmann区:19)，在ToMA加工过程中，SPQ总分与大脑激活呈正相关。在ToMA加工过程中，右侧枕下回、右侧MTG、楔前叶和后扣带皮层与情绪断开亚分和共情自我报告总分呈负相关。在非临床个体中，这些脑后区域被认为与记忆、语言以及创造性推理有关。我们的研究结果强调了非临床个体在ToMA而非ToMC加工过程中与特质分裂型相关的大脑加工过程的变化。

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来源期刊

Social cognitive and affective neuroscience 医学-神经科学

CiteScore

6.80

自引率

4.80%

发文量

审稿时长

4-8 weeks

期刊介绍： SCAN will consider research that uses neuroimaging (fMRI, MRI, PET, EEG, MEG), neuropsychological patient studies, animal lesion studies, single-cell recording, pharmacological perturbation, and transcranial magnetic stimulation. SCAN will also consider submissions that examine the mediational role of neural processes in linking social phenomena to physiological, neuroendocrine, immunological, developmental, and genetic processes. Additionally, SCAN will publish papers that address issues of mental and physical health as they relate to social and affective processes (e.g., autism, anxiety disorders, depression, stress, effects of child rearing) as long as cognitive neuroscience methods are used.