Virological and Pathological Diagnosis of Canine Oral Papillomavirus in Dogs and Evaluation of Treatment Applications

Abstract

Background: The canine oral papillomavirus (CoPV) is the cause of oral papillomatosis in all dogs. The purpose of this study is to compare two treatment methods after virological and pathological diagnosis of oral papillomas. Methods: Blood samples were collected from 50 owned and stray dogs of various breeds. The presence of CoPV antigen (Ag) in the blood samples investigated. Tissue samples from the papilloma mass were collected for auto vaccination and histopathological examination. CoPV (Ag) was found in the blood of dogs with papilloma lesions who were randomly divided and treated into two groups. While group 1 receives autologous vaccines and immune-supportive ZylexisTM, Group 2 receives PAPILENDTM® cream, immune-boosting ZylexisTM and premix powder (vitamin E, zinc, selenium, copper). Result: The dogs have an average age of 31.9+7.4 months. CoPV (Ag) was detected in half of all dogs with papilloma lesions. The histopathological examination typically revealed an increased epidermal layer. In the treatment of group 1, the mean remission period was 21-30 days. This period was determined to be 15-30 days in 15 animals from the second treatment group. Lesions were successfully treated in all dogs with CoPV (Ag) in both groups. The combination of PAPILENDTM® cream, immune-supportive ZylexisTM and premix powder was found to shorten the disease remission period caused by CoPV oral lesions.