HYPOGLYCAEMIC ACTIVITY OF DIFFERENT FRACTIONS OF BERBERIS ARISTATA ROOT-BARK IN NORMAL AND ALLOXAN DIABETIC RABBITS

M. Akhtar
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引用次数: 12

Abstract

A number of plants including Berberis aristata roots are considered effective as antidiabetic agents in ethnomedical practices. In this study effects of certain isolated fractions from root-bark of Berberis aristata on blood glucose levels were determined in normal and alloxan-diabetic rabbits. In normal rabbits, ethanolic fraction in 0.5, 1.0 and 1.5 g/kg produced significant decrease (P<0.05 or 0.001) at 8 and 12 hrs. Its acidified-basified fraction showed significant lowering of blood sugar at 2, 4, 8 and 12 hrs. The chloroform: methanol fraction also produced significant hypoglycaemic effect at these intervals. In alloxan-diabetic rabbits, ethanolic fraction in doses similar to normal animals produced significant decrease in blood glucose at 2, 4, 8 and 12 hrs.
小檗不同部位对正常和四氧嘧啶型糖尿病家兔的降糖作用
包括小檗根在内的一些植物在民族医学实践中被认为是有效的抗糖尿病药物。本研究采用四氧嘧啶型糖尿病家兔,测定了小檗皮分离物对正常家兔和四氧嘧啶型糖尿病家兔血糖的影响。在正常家兔中,0.5、1.0和1.5 g/kg的乙醇含量在8和12 h时显著降低(P<0.05或0.001)。其酸化碱化部分在2、4、8和12小时的血糖均有显著降低。在这些时间间隔内,氯仿甲醇馏分也产生了显著的降糖作用。在四氧嘧啶糖尿病家兔中,剂量与正常动物相似的乙醇组分在2、4、8和12小时的血糖显著降低。
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