Enhanced antibacterial effect by antibiotic loaded starch nanoparticle

Abstract

The soluble form of starch nanoparticle (SNP) is used for its advantage to encapsulate the antibiotics. In this study, SNP encapsulated antibiotics were introduced to the bacterium, Streptococcus pyogenes and the inhibitory effect was studied. The preparation of SNP loaded antibiotics was carried out using microemulsion nanoprecipitation method which does not require sophisticated equipment, hazardous reagents and extreme conditions. The starch was dissolved in urea alkaline solution and precipitated in ethanolic emulsion system which yields smaller sized nanoparticles with larger surface area thus increasing the efficiency of low water soluble drug molecules loading. The SNP obtained are not vulnerable to clumping. The antimicrobial study was done using the disk diffusion test with different amounts of starch loaded with antibiotics. The encapsulation of single/multiple antibiotics and their inhibition is an indicator of the efficacy of SNPs. This study improved the effectiveness of drugs capability that are produced from a cheap source that brought about a large impact.