Mechanics of Microsporidian Polar Tube Firing.

Q2 Medicine
Pattana Jaroenlak, Mahrukh Usmani, Damian C Ekiert, Gira Bhabha
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引用次数: 0

Abstract

As obligate intracellular parasites with reduced genomes, microsporidia must infect host cells in order to replicate and cause disease. They can initiate infection by utilizing a harpoon-like invasion organelle called the polar tube (PT). The PT is both visually and functionally a striking organelle and is a characteristic feature of the microsporidian phylum. Outside the host, microsporidia exist as transmissible, single-celled spores. Inside each spore, the PT is arranged as a tight coil. Upon germination, the PT undergoes a large conformational change into a long, linear tube and acts as a tunnel for the delivery of infectious cargo from the spore to a host cell. The firing process is extremely rapid, occurring on a millisecond timescale, and the emergent tube may be as long as 20 times the size of the spore body. In this chapter, we discuss what is known about the structure of the PT, the mechanics of the PT firing process, and how it enables movement of material from the spore body.

微孢子虫极管烧成的力学。
作为基因组减少的专性细胞内寄生虫,微孢子虫必须感染宿主细胞才能复制并引起疾病。它们可以利用一种叫做极管(PT)的鱼叉状入侵细胞器来引发感染。PT在视觉上和功能上都是一个显著的细胞器,是微孢子虫门的一个特征。在寄主外,微孢子虫以可传播的单细胞孢子存在。在每个孢子内,PT排列成一个紧密的线圈。在萌发时,芽孢体经历了一个大的构象变化,变成一个长而线性的管,并作为一个通道,将感染性货物从孢子运送到宿主细胞。燃烧过程非常迅速,在毫秒的时间尺度上发生,并且涌现管可能长达孢子体大小的20倍。在本章中,我们讨论了关于PT的结构,PT燃烧过程的机制,以及它如何使材料从孢子体中移动。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Experientia supplementum (2012)
Experientia supplementum (2012) Medicine-Medicine (all)
CiteScore
3.30
自引率
0.00%
发文量
24
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