Levels and clinical significance of homocysteine in serum and D-dimer in plasma of patients with non-small cell lung cancer

Central Plains Medical Journal Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.1674-4756.2020.04.010

Yu-jiao Feng, Yan Kang, Caili Pei, Xue-ying Tian

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Abstract

Objective To investigate the levels and clinical significance of homocysteine in serum and D-dimer in plasma of patients with non-small cell lung cancer . Methods A total of 126 patients with non-small cell lung cancer who were admitted to Shanxi Provincial Cancer Hospital from June 2016 to July 2019 were selected as the study group, another 126 healthy people who came to hospital for physical examination during the same period were selected as the control group. The serum homocysteine and plasma D-dimer were detected in both groups, and the results were compared between the two groups and within the study group (before and after treatment). Results The serum homocysteine and plasma D-dimer levels in study group were higher than those in control group (P<0.05). In study group, the serum homocysteine and plasma D-dimer levels after treatment were lower than those before treatment (P<0.05). Conclusions Serum homocysteine and plasma D-dimer levels can be used as the main reference in the diagnosis of non-small cell lung cancer. Key words: Non-small cell lung cancer; Homocysteine; D-dimer

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非小细胞肺癌患者血清同型半胱氨酸及血浆d -二聚体水平及临床意义

目的探讨非小细胞肺癌患者血清同型半胱氨酸和血浆d -二聚体水平及临床意义。方法选取2016年6月至2019年7月山西省肿瘤医院收治的非小细胞肺癌患者126例为研究组，同期来医院体检的健康人群126例为对照组。检测两组患者血清同型半胱氨酸和血浆d -二聚体水平，并比较两组间及研究组内(治疗前后)结果。结果研究组患者血清同型半胱氨酸和血浆d -二聚体水平均高于对照组(P<0.05)。研究组患者治疗后血清同型半胱氨酸、血浆d -二聚体水平均低于治疗前(P<0.05)。结论血清同型半胱氨酸和血浆d -二聚体水平可作为诊断非小细胞肺癌的主要参考指标。关键词:非小细胞肺癌;同型半胱氨酸;肺动脉栓塞

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Central Plains Medical Journal

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