ROLE OF LIPOPOLYSACCHARIDE IN DEVELOPMENT OF SEPSIS (REVIEW)

Q4 Computer Science

Computer Research and Modeling Pub Date : 2023-07-08 DOI:10.37539/230503.2023.43.67.002

Татьяна Ивановна Хомякова, Ольга Михайловна Рябинина

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引用次数: 0

Abstract

Липополисахариды грамотрицательных бактерий (LPS) считаются наиболее иммуногенными бактериальными компонентами, ассоциированными с развитием системного воспаления и сепсиса. В обзоре описываются механизмы действия LPS на основные органы-мишени,- легкие, сердце и головной мозг тяжелое поражение которых ассоциировано с развитием дыхательной и сердечной недостаточности. Gram-negative bacterial lipopolysaccharides (LPS) are considered to be the most immunogenic bacterial components associated with the development of systemic inflammation and sepsis. The review describes the mechanisms of action of LPS on the main target organs - the lungs, heart and brain, the severe damage of which is associated with the development of respiratory and heart failure.

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来源期刊

Computer Research and Modeling Computer Science-Computational Theory and Mathematics

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

15 weeks

期刊介绍： The journal publishes original research papers and review articles in the field of computer research and mathematical modeling in physics, engineering, biology, ecology, economics, psychology etc. The journal covers research on computer methods and simulation of systems of various nature in the leading scientific schools of Russia and other countries. Of particular interest are papers devoted to simulation in thriving fields of science such as nanotechnology, bioinformatics, and econophysics. The main goal of the journal is to cover the development of computer and mathematical methods for the study of processes in complex structured and developing systems. The primary criterion for publication of papers in the journal is their scientific level. The journal does not charge a publication fee. The decision made on publication is based on the results of an independent review. The journal is oriented towards a wide readership – specialists in mathematical modeling in various areas of science and engineering. The scope of the journal includes: — mathematical modeling and numerical simulation; — numerical methods and the basics of their application; — models in physics and technology; — analysis and modeling of complex living systems; — models of economic and social systems. New sections and headings may be included in the next volumes.