In Vitro Release of a Tumor‐Antigen (TA‐4) by Human Cervical Squamous Cell Carcinoma

Abstract

The release of a human squamous cell carcinoma antigen (TA-4) was studied by in vitro incubation of squamous cell carcinoma tissues and normal squamous epithelium of the uterine cervix. TA-4 activity was determined by a radioimmunoassay method using a monospecific antiserum to TA-4. TA-4 activity was found in both malignant and non-malignant tissues. However, the malignant tissue released significantly larger amounts of TA-4 than the non-malignant tissue during 72 hours incubation.