Efficacy of single dose of phenytoin/fosphenytoin in benign convulsions with mild gastroenteritis.

IF 0.8 4区医学 Q4 PEDIATRICS

Turkish Journal of Pediatrics Pub Date : 2023-01-01 DOI:10.24953/turkjped.2021.4574

Keun Soo Lee, Bo Lyun Lee

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引用次数: 1

Abstract

Background: This study evaluated the efficacy of a single dose of phenytoin/fosphenytoin (PHT) to control repetitive seizures in children with benign convulsions with mild gastroenteritis (CwG).

Methods: Children aged between 3 months and 5 years with CwG were retrospectively enrolled. Convulsions with mild gastroenteritis were defined as (a) seizures with acute gastroenteritis without fever or dehydration; (b) normal blood laboratory results; and (c) normal electroencephalography and brain imaging findings. Patients were divided into two groups according to whether or not intravenous PHT (10 mg/kg of phenytoin or phenytoin equivalents) was administered. Clinical manifestations and treatment efficacy were evaluated and compared.

Results: Ten of 41 children eligible for inclusion received PHT. Compared to children in the non-PHT group, those in the PHT group had a higher number of seizures (5.2 ± 2.3 vs. 1.6 ± 1.0, P < 0.001) and a lower serum sodium level (133.5 ± 3.2 mmol/L vs. 137.2 ± 2.6 mmol/L, P = 0.001). Initial serum sodium levels were negatively correlated with seizure frequency (r = -0.438, P = 0.004). In all patients, seizures were completely resolved with a single dose of PHT. There were no significant adverse effects from PHT.

Conclusions: A single dose of PHT can effectively treat CwG with repetitive seizures. The serum sodium channel may play a role in seizure severity.

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单剂量苯妥英/磷妥英治疗轻度胃肠炎伴良性惊厥的疗效观察。

背景:本研究评估了单剂量苯妥英/磷妥英(PHT)对轻度胃肠炎(CwG)患儿良性惊厥反复发作的控制效果。方法:对年龄在3个月至5岁的CwG患儿进行回顾性研究。痉挛伴轻度肠胃炎定义为(a)癫痫伴急性肠胃炎，无发热或脱水;(b)血液化验结果正常;(c)正常脑电图和脑成像结果。根据是否静脉注射PHT (10 mg/kg苯妥英或苯妥英当量)将患者分为两组。评价和比较两组患者的临床表现和治疗效果。结果:41名符合纳入条件的儿童中有10名接受了PHT治疗。与非PHT组相比，PHT组患儿癫痫发作次数较高(5.2±2.3次vs. 1.6±1.0次，P < 0.001)，血清钠水平较低(133.5±3.2 mmol/L vs. 137.2±2.6 mmol/L, P = 0.001)。初始血清钠水平与癫痫发作频率呈负相关(r = -0.438, P = 0.004)。在所有患者中，单剂量PHT完全消除了癫痫发作。PHT没有明显的不良反应。结论:单剂量PHT可有效治疗CwG反复发作。血清钠通道可能在癫痫发作的严重程度中起作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Pediatrics 医学-小儿科

CiteScore

1.40

自引率

0.00%

发文量

122

审稿时长

6-12 weeks

期刊介绍： The Turkish Journal of Pediatrics is a multidisciplinary, peer reviewed, open access journal that seeks to publish research to advance the field of Pediatrics. The Journal publishes original articles, case reports, review of the literature, short communications, clinicopathological exercises and letter to the editor in the field of pediatrics. Articles published in this journal are evaluated in an independent and unbiased, double blinded peer-reviewed fashion by an advisory committee.