Development of a combined CMV-UL97 C592F and CMV-UL54 T503I resistance mutation during ganciclovir treatment in a kidney transplant recipient

Q3 Medicine

Reviews in Medical Microbiology Pub Date : 2019-10-01 DOI:10.1097/MRM.0000000000000190

M. Karrasch, D. Michel, S. Schneider, M. Baier, M. Busch

引用次数: 0

Abstract

ISSN In CMV high-risk kidney transplant recipients (KTR), recommended antiviral human cytomegalovirus (CMV) treatment can lead to nephrotoxicity and antiviral resistance. In this case report, we report the development of a combined CMV-UL97 C592F and CMV UL54 T503I resistance mutation in a high-risk KTR most probably linked to the previous treatment with valganciclovir (valGCV) and ganciclovir (GCV). Routine CMV screening, in addition with testing of CMV immunity and applied stewardship programs for ganciclovir might have been helpful in preventing the development of these mutations in this patient. Copyright 2019 Wolters Kluwer Health, Inc. All rights reserved.

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更昔洛韦治疗肾移植受者期间CMV-UL97 C592F和CMV-UL54 T503I联合耐药突变的发展

在CMV高危肾移植受者(KTR)中，推荐的抗病毒人巨细胞病毒(CMV)治疗可导致肾毒性和抗病毒耐药性。在本病例报告中，我们报告了CMV- ul97 C592F和CMV UL54 T503I联合耐药突变在高危KTR中的发展，最有可能与先前使用缬更昔洛韦(valGCV)和更昔洛韦(GCV)治疗有关。常规巨细胞病毒筛查，再加上巨细胞病毒免疫测试和更昔洛韦的应用管理计划，可能有助于预防该患者发生这些突变。版权所有2019威科健康有限公司版权所有。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reviews in Medical Microbiology 生物-微生物学

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Reviews in Medical Microbiology is a quarterly review journal which provides a balanced coverage of the whole field of medical microbiology. The Journal publishes state-of-the art reviews, mini-reviews, case presentations and original research from on-going research of the latest developments and techniques in medical microbiology, virology, mycology, parasitology, clinical microbiology, and hospital infection. In addition, PhD-Review - a platform for young researchers, and biographical Bio-Sketch articles are also considered. Reviews are concise, authoritative, and readable synthesis of the latest information on its subject, and references are limited to the fifty key sources for full reviews and twenty for mini-reviews. Reviews in Medical Microbiology is the perfect way for both qualified and trainee microbiologists, and researchers and clinicians with an interest in microbiology, to stay fully informed of the latest developments in medical microbiology. The journal is a valuable resource for educational and teaching purposes.