Development and the Effectiveness of a Nasal Breathing Stimulator Combined with an Oral Appliance for Treating Obstructive Sleep Apnea

Arisa Sawa, Hiroshi Suzuki, H. Niwa, Tatsuo Yagi, S. Oguchi, Y. Makiyama, C. Chow, O. Komiyama
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Abstract

Objective: Many obstructive sleep apnea(OSA)patients have nasal obstruction. Further, most patients discontinue wearing an oral appliance(OA)for improving respiration due to nasal obstruction. We aimed to develop a nasal breathing stimulator(NBS)for use in combination with an OA to promote nasal breathing. Methods: Thirteen OSA patients wore a NBS, Max-Air Nose Corns ® , Mute with hole ® , which expands the nasal cavity from the inside, and Breathe Right ® , which expands the nasal cavity from the outside, and compared the resultant changes in respiratory measures with those when a device was not used. The inspiratory flow rate(peak nasal inspiratory flow: PNIF)and visual analogue scale(VAS)scores were measured under five conditions. Furthermore, PNIF was measured under four conditions: OA(-)NBS(-), OA(+)NBS(-), OA(-)NBS(+), and OA(+)NBS(+), and a sleep test was performed. Results: PNIF was significantly higher when wearing an NBS compared with the other four devices(p < 0.001). In addition, PNIF was significantly higher in OA(+)NBS(+) than that in the other three conditions(p < 0.001), and OA(+)NBS(+)improved the respiratory disturbance index(p < 0.001), lowest SpO 2( p < 0.001), and Epworth sleepiness scale(ESS)score(p < 0.001)on the sleep test. Discussion: Wearing the NBS improved breathing in patients who did not benefit from OA treatment alone and in those who discontinued OA use due to nasal obstruction.
鼻呼吸刺激器联合口腔器械治疗阻塞性睡眠呼吸暂停的发展与效果
目的:许多阻塞性睡眠呼吸暂停(OSA)患者存在鼻塞。此外,大多数患者由于鼻塞而停止佩戴口腔矫治器(OA)以改善呼吸。我们的目标是开发一种鼻呼吸刺激器(NBS),用于与OA结合使用,以促进鼻腔呼吸。方法:13例OSA患者佩戴NBS、Max-Air鼻镜®、Mute with hole®(从内扩张鼻腔)和Breathe Right®(从外扩张鼻腔),比较其与未使用设备时呼吸测量的变化。测量5种情况下的吸气流量(峰值鼻吸气流量:PNIF)和视觉模拟评分(VAS)。此外,在OA(-)NBS(-)、OA(+)NBS(-)、OA(-)NBS(+)和OA(+)NBS(+)四种情况下测量PNIF,并进行睡眠测试。结果:与其他四种设备相比,佩戴NBS时PNIF明显更高(p < 0.001)。此外,OA(+)NBS(+)组的PNIF显著高于其他三种情况(p < 0.001), OA(+)NBS(+)组改善了睡眠测试的呼吸障碍指数(p < 0.001)、最低SpO 2(p < 0.001)和Epworth嗜睡量表(ESS)评分(p < 0.001)。讨论:佩戴NBS改善了没有从单独OA治疗中获益的患者以及因鼻塞而停止OA治疗的患者的呼吸。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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