S. Rajendran, C. Salas, Thalía Delgado, J. Bertrand, I. Brito
{"title":"Synthesis of polycyclic quinolines using SiO2/H2SO4 via Friedlӓnder synthetic method","authors":"S. Rajendran, C. Salas, Thalía Delgado, J. Bertrand, I. Brito","doi":"10.3390/ecsoc-23-06491","DOIUrl":null,"url":null,"abstract":"Graphical Abstract Abstract An attention to the novel synthetic route for the polycyclic quinolines ( 3 & 5 ) from cyclic-diketones, with o-aminoarylketones ( 1 ) in the presence of SiO 2 /H 2 SO 4 yielded via Friedlӓnder synthetic method. The catalytic efficiency of the SiO 2 /H 2 SO 4 was discussed through their utilization in the synthesis of biologically active substituted polycyclic quinoline derivatives ( 3 & 5 ) and the mechanism has been proposed. The SiO 2 /H 2 SO 4 was found as a effective catalyst for the Friedlӓnder reaction and gave considerable isolated yield of the targeted products under the mild reaction condition. The synthesized polycyclic quinolines ( 3 & 5 ) were characterized through diverse analytical techniques like FT-IR, NMR spectroscopy and single crystal X-ray diffraction studies.","PeriodicalId":20537,"journal":{"name":"Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2019-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of The 23rd International Electronic Conference on Synthetic Organic Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecsoc-23-06491","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Graphical Abstract Abstract An attention to the novel synthetic route for the polycyclic quinolines ( 3 & 5 ) from cyclic-diketones, with o-aminoarylketones ( 1 ) in the presence of SiO 2 /H 2 SO 4 yielded via Friedlӓnder synthetic method. The catalytic efficiency of the SiO 2 /H 2 SO 4 was discussed through their utilization in the synthesis of biologically active substituted polycyclic quinoline derivatives ( 3 & 5 ) and the mechanism has been proposed. The SiO 2 /H 2 SO 4 was found as a effective catalyst for the Friedlӓnder reaction and gave considerable isolated yield of the targeted products under the mild reaction condition. The synthesized polycyclic quinolines ( 3 & 5 ) were characterized through diverse analytical techniques like FT-IR, NMR spectroscopy and single crystal X-ray diffraction studies.