Hepatitis B Virus Infection as a Risk Factor for Developing Diabetes Mellitus: A Meta-Analysis of a Large Observational Studies

M. Sari, Clarissa Agdelina, D. Bahri, Nadya Regina Permata, J. A. Trixie
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Abstract

Background: There are a lot of theories about how Hepatitis B Virus (HBV) infection affects many diseases, one of them is Diabetes Mellitus (DM). However, the relation remains controversial between DM and HBV as an infection. This study aims to evaluate HBV infection as a risk factor for developing DM.Method: A systematic review was performed using medical search engines such as Pubmed, ScienceDirect and GoogleScholar. References until February 2021 that met the inclusion criteria were reviewed. The primary outcome was the prevalence of DM. Authors also perform Subgroup analyses based on study type. The extracted data were analyzed using RevMan 5.4 application.Results: A total of 20 studies were analyzed with 245,468,411 subjects included. In which divided into two groups, patients with HBV infected group and non infected HBV group. Authors found that there is a statistically difference between patients with HBV infected groups and non infected HBV groups on the primary outcome which is the prevalence of DM (OR 1.24; 95% CI, 1.10-1.41; p = 0.0006). Authors also found the same results based on study type both in case-control (OR = 1.76; 95% CI: 1.08-2.85; p = 0.02) and cross-sectional (OR = 1.40; 95% CI: 1.05-1.85; p = 0.02) studies. Meanwhile in Cohort studies the results show no statistically significant difference between the two groups (OR = 1.07; 95% CI: 0.87-1.33; p = 0.52). Conclusion:  HBV infected patients have a higher risk of developing DM than patients without HBV infection. 
乙型肝炎病毒感染是发生糖尿病的危险因素:一项大型观察性研究的荟萃分析
背景:关于乙型肝炎病毒(HBV)感染如何影响多种疾病的理论很多,其中之一是糖尿病(DM)。然而,作为一种感染,糖尿病和HBV之间的关系仍然存在争议。方法:使用Pubmed、ScienceDirect和GoogleScholar等医学搜索引擎进行系统综述。审查2021年2月之前符合纳入标准的参考文献。主要结果是糖尿病的患病率。作者还根据研究类型进行了亚组分析。采用RevMan 5.4软件对提取的数据进行分析。结果:共纳入20项研究,共纳入245,468,411名受试者。其中分为两组,患者HBV感染组和未感染HBV组。作者发现,HBV感染组和非HBV感染组患者在主要终点DM患病率方面存在统计学差异(OR 1.24;95% ci, 1.10-1.41;P = 0.0006)。作者还在病例对照中发现了相同的结果(OR = 1.76;95% ci: 1.08-2.85;p = 0.02)和横截面(OR = 1.40;95% ci: 1.05-1.85;P = 0.02)研究。同时,在队列研究中,两组结果无统计学差异(OR = 1.07;95% ci: 0.87-1.33;P = 0.52)。结论:HBV感染患者发生糖尿病的风险高于未感染的患者。
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