ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1.

Journal of college and character Pub Date : 2022-06-01 eCollection Date: 2022-01-01 DOI:10.1155/2022/4446805

Peng Liu, Yan Zhou, Xin Dong, Biao Zheng, Bo Liang, Rui Liang, Zhong Liu, Li Li, Peng Gong

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Abstract

The strong tumorigenic capacity and treatment resistance made hepatocellular carcinoma (HCC) a huge threat to public health. ZNF165, the kruppel family of zinc-finger-containing transcription factors, is expressed in HCC; however, its specific role in HCC and the molecular mechanism are yet to be elucidated. In this study, we observed that ZNF165 was overexpressed in liver cancer tissues and the immune microenvironment; higher ZNF165 expression was correlated with lower overall survival in liver cancer patients. The ZNF165 knockdown in Bel7402 cells revealed the impairment of the tryptophan/kynurenine/AhR/CYP1A1 axis. Moreover, the knockdown of CYP1A1 significantly inhibited the proliferation and migration of HCC cells, and ZNF165 promoted the transcriptional activity of AhR by facilitating the nuclear translocation of CYP1A1. In conclusion, the present study argued that ZNF165 was highly expressed in liver tissues and the immune microenvironment. ZNF165 promoted the proliferation and migration of HCC cells by activating the tryptophan/kynurenine/AhR/CYP1A1 axis and promoting the expression of CYP1A1.

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ZNF165参与调节免疫微环境并通过AhR/CYP1A1促进肝细胞癌的增殖和迁移

肝细胞癌（HCC）具有很强的致癌能力和耐药性，对公众健康构成巨大威胁。ZNF165是含锌指转录因子克虏伯家族的一种转录因子，在HCC中也有表达，但其在HCC中的特异性作用及其分子机制尚待阐明。在本研究中，我们观察到 ZNF165 在肝癌组织和免疫微环境中过表达；ZNF165 的高表达与肝癌患者总生存率的降低相关。在 Bel7402 细胞中敲除 ZNF165 后，发现色氨酸/犬尿氨酸/AhR/CYP1A1 轴受损。此外，敲除 CYP1A1 能显著抑制 HCC 细胞的增殖和迁移，ZNF165 通过促进 CYP1A1 的核转位来促进 AhR 的转录活性。总之，本研究认为 ZNF165 在肝组织和免疫微环境中高表达。ZNF165通过激活色氨酸/犬尿氨酸/AhR/CYP1A1轴和促进CYP1A1的表达，促进了HCC细胞的增殖和迁移。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Journal of college and character

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