The effect of troxerutin on alterations of lipid profile and biochemical enzymes in blood of rats with chronic diabetes

Abstract

Background & Aims : Diabetes Mellitus (DM) is a progressive disease that leads to complex disorders such as biochemical changes in the blood. The use of medicinal plants are superior to synthetic drugs because of the few side-effects in disease prevention. In this study, we examined the effect of troxerutin on lipid profile and biochemical enzymes in the blood of type 1 diabetic rats. Materials & Methods : 32 male Wistar rats (200-250) were randomly divided into four groups: control, diabetes, control+ troxerutin, diabetes+ troxerutin. Type 1 diabetes was induced by i.p injection of streptozotocin (50 mg/kg) in animals in diabetic groups. Lasted for 4 weeks, oral administration of troxerutin (150 mg/kg) was carried daily for 4 weeks. At the end of study, anesthesia was induced intraperitoneally with sodium pentobarbital (mg / kg 60). Blood samples was collected for measuring lipid profile and biochemical enzymes in blood of rats. Results: Diabete significantly increased LDL, COL, TG and significantly decreased HDL compared to the control group. Treatment diabetic rats with troxerutin for 4 weeks significantly decreased LDL, COL, TG and significantly increased HDL.furthermore, Diabetes significantly increased ALT, AST, LDH, and CPK in blood of rats. Treatment diabetic rats with troxerutin for 4 weeks significantly decreased ALT, AST, LDH, and CPK in blood of rats compared to the control group. Conclusion : Troxerutin improve the lipid profile and reduce biochemical enzymes in blood of diabetic rats.In this way could be useful in reducing the complications of diabetes. KeyWords: Diabetes; Troxerutin; biochemical enzymes; lipid profile; rat