Cameron R. Love, Sumit Gautam, Chamala Lama, Nhu Hoa Le, Brigitte Dauwalder
{"title":"The Drosophila dopamine 2-like receptor D2R (Dop2R) is required in the blood brain barrier for male courtship","authors":"Cameron R. Love, Sumit Gautam, Chamala Lama, Nhu Hoa Le, Brigitte Dauwalder","doi":"10.1111/gbb.12836","DOIUrl":null,"url":null,"abstract":"<p>The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult <i>Drosophila</i> BBB is required for normal male courtship behavior and relies on male-specific molecules in the BBB. Here we show that the dopamine receptor <i>D2R</i> is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of <i>D2R</i> in BBB cells causes courtship defects. The courtship defects observed in genetic <i>D2R</i> mutants can be rescued by expression of normal <i>D2R</i> specifically in the BBB of adult males. <i>Drosophila</i> BBB cells are glial cells. Our findings thus identify a specific glial function for the <i>DR2</i> receptor and dopamine signaling in the regulation of a complex behavior.</p>","PeriodicalId":50426,"journal":{"name":"Genes Brain and Behavior","volume":"22 1","pages":""},"PeriodicalIF":2.4000,"publicationDate":"2023-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0b/47/GBB-22-e12836.PMC9994173.pdf","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes Brain and Behavior","FirstCategoryId":"102","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/gbb.12836","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 3
Abstract
The blood brain barrier (BBB) has the essential function to protect the brain from potentially hazardous molecules while also enabling controlled selective uptake. How these processes and signaling inside BBB cells control neuronal function is an intense area of interest. Signaling in the adult Drosophila BBB is required for normal male courtship behavior and relies on male-specific molecules in the BBB. Here we show that the dopamine receptor D2R is expressed in the BBB and is required in mature males for normal mating behavior. Conditional adult male knockdown of D2R in BBB cells causes courtship defects. The courtship defects observed in genetic D2R mutants can be rescued by expression of normal D2R specifically in the BBB of adult males. Drosophila BBB cells are glial cells. Our findings thus identify a specific glial function for the DR2 receptor and dopamine signaling in the regulation of a complex behavior.
期刊介绍:
Genes, Brain and Behavior was launched in 2002 with the aim of publishing top quality research in behavioral and neural genetics in their broadest sense. The emphasis is on the analysis of the behavioral and neural phenotypes under consideration, the unifying theme being the genetic approach as a tool to increase our understanding of these phenotypes.
Genes Brain and Behavior is pleased to offer the following features:
8 issues per year
online submissions with first editorial decisions within 3-4 weeks and fast publication at Wiley-Blackwells
High visibility through its coverage by PubMed/Medline, Current Contents and other major abstracting and indexing services
Inclusion in the Wiley-Blackwell consortial license, extending readership to thousands of international libraries and institutions
A large and varied editorial board comprising of international specialists.