Evaluation of antidiabetic role of Bridelia ferruginea methanol leaf extract in streptozocin induced diabetic male wistar rats

Abstract

Diabetes mellitus (DM) is a chronic disease characterized by hyperglycemia.1 DM occurs either when the pancreas does not produce insulin, or when the body cannot effectively use the insulin it produces.2 Several findings has revealed that DM is a major global health concern with a projected rise in prevalence from 171 million in 2010 to 366 million 2030.2,3 Both the number of cases and the prevalence of DM has steadily being on a rise over the past few decades and it is regarded to be a silent killer disease, affecting millions of peoples in the world.4,5 In Africa, the number of people with diabetes will increase from 14.2 million in 2015 to 34.2 million in 2040 predominantly populated in some of the region’s most populous countries: South Africa, the Democratic Republic of Congo, Nigeria and Ethiopia.3,4,6