Biochemical markers of oxidative stress in patients with inflammatory bowel diseases

Abstract

Introduction: Inflammatory bowel disease (IBD) is a group of diseases of unexplained aetiology, charac - terized by periods of remissions and exacerbations. Reactive oxygen species (ROS) as far as disorders of balance between levels of prooxidants and antioxidants may also participate in the occurrence of IBD. The aim of the present study was an assessment of the antioxidative barrier of the organism in patients with inflammatory bowel disease. Material and methods: The study group consisted of 99 patients (80 with IBD as a study group and 19 healthy as a control group) from Jan Biziel University Hospital in Bydgoszcz, Poland. Venous blood was the material for biochemical analysis: HT, GSH, GPX p , GPX RBC , GST, GR, SOD-1, MDA, NO 2/NO 3-and CP. Results: There were statistically significant differences in oxidative stress parameters observed between the study group and the control group, especially concerning HT, GSH, GPX RBC , GST, SOD-1, MDA and NO 2/NO 3. Discussion: The assumption that increased activity of antioxidative compounds may constitute a defence against the influence of oxidative stress may be true. Their decreased activity may participate in lowering an organism’s abilities to defend against oxidative stress and cause the development of free radical diseases. Further studies into targeted preventive strategies are needed. Conclusions: Prooxidative factors play an essential role in the pathogenesis of IBD. Due to the still un - known etiopathology of IBD, research on imbalances between pro-oxidants and antioxidants should be continued in larger groups of patients.