Refractory Hidradenitis Suppurativa: A Diagnosis to Consider.

IF 1.6 3区物理与天体物理 Q3 PHYSICS, FLUIDS & PLASMAS

High Energy Density Physics Pub Date : 2023-01-05 eCollection Date: 2024-02-01 DOI:10.1159/000528432

Rita Ornelas Saraiva, Christopher Saunders, Margarida Varela Dos Santos, Diana Carvalho, Rafaela Loureiro, Jaime Ramos

引用次数: 0

Abstract

Hidradenitis suppurativa is a chronic inflammatory disease associated with multiple comorbidities, and its association with lymphoma has recently been a topic of debate. However, it is still controversial whether this risk can be attributed to the disease itself or whether it has any relationship with immunosuppressive treatment. Here, we describe the case of a patient with severe perianal hidradenitis suppurativa treated with methotrexate and infliximab, whose exacerbation with persistence of severe symptoms refractory to adequate treatment led to the diagnosis of diffuse large non-Hodgkin B-cell lymphoma. It was decided to perform a colostomy to improve perianal sepsis, and immunochemotherapy was proposed.

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难治性湿疹：需要考虑的诊断

化脓性扁平湿疹是一种与多种并发症相关的慢性炎症性疾病，它与淋巴瘤的关系最近一直是一个争论的话题。然而，这种风险是否可归因于疾病本身，或者是否与免疫抑制治疗有关，目前仍存在争议。在此，我们描述了一例接受甲氨蝶呤和英夫利昔单抗治疗的严重肛周化脓性扁桃体炎患者的病例，该患者病情加重，症状持续严重，经适当治疗无效，最终被诊断为弥漫性大非霍奇金B细胞淋巴瘤。医生决定进行结肠造口术以改善肛周败血症，并建议采用免疫化疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

High Energy Density Physics PHYSICS, FLUIDS & PLASMAS-

CiteScore

4.20

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： High Energy Density Physics is an international journal covering original experimental and related theoretical work studying the physics of matter and radiation under extreme conditions. ''High energy density'' is understood to be an energy density exceeding about 1011 J/m3. The editors and the publisher are committed to provide this fast-growing community with a dedicated high quality channel to distribute their original findings. Papers suitable for publication in this journal cover topics in both the warm and hot dense matter regimes, such as laboratory studies relevant to non-LTE kinetics at extreme conditions, planetary interiors, astrophysical phenomena, inertial fusion and includes studies of, for example, material properties and both stable and unstable hydrodynamics. Developments in associated theoretical areas, for example the modelling of strongly coupled, partially degenerate and relativistic plasmas, are also covered.