Genotypic Characteristics of Outpatient Antibiotic Resistance and Nosocomial Staphylococcus aureus Strains

Abstract

The article presents the results of a study of antibiotic resistance of 191 methicillin-sensitive (MSSA) and methicillin-resistant (MRSA) strains Staphylococcus aureus (S. aureus), isolated from outpatient and hospital patients. The data of molecular-genetic typing of strains of S. aureus and established types of SCCmec cassettes. There were significant differences in the sample genotype MRSA strains isolated from patients and hospital outpatient profile. Isolates from outpatients, contained in its composition genetic elements SCCmec IV a, c, d types. MRSA, isolates from hospital patients profile were identified only type II SCCmec cassettes. Vancomycin, fusidic acid, mupirocin antistaphylococcal possessed high activity against MRSA and MSSA. MRSA were more resistant to antimicrobial drugs compared to MSSA. Azithromycin and clindamycin demonstrated moderate anti-staphylococcal activity. Revealed low activity of chloramphenicol, tetracycline and erythromycin against staphylococci strains.