A Retrospective Single-center Study of Presentation and Prognosis of Guillain-Barré Syndrome in Pediatric Patients

IF 0.4 4区医学 Q4 PEDIATRICS

Iranian Journal of Pediatrics Pub Date : 2023-02-10 DOI:10.5812/ijp-128852

M. Nasehi, P. Ahmadi, Z. Khalili, Maryam Rahmannia, Zahra Ahmadi, Mahmoud Reza Zitatzadeh, E. Pourbakhtyaran

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Abstract

Background: Guillain-Barré syndrome (GBS) is a post-infectious immune-mediated peripheral neuropathy, progressing bilaterally and often symmetrically and affecting sensory and motor function. Most cases completely recover, but around 20% of cases may lead to complications, incomplete recovery, or even death. Objectives: This study aims to assess the prognosis of GBS in pediatric patients and possible associated conditions regarding recovery or prognosis. Methods: We investigated 71 cases of GBS admitted to Mofid Pediatric Hospital from March 2014 to March 2017. Demographic, clinical, and laboratory data were retrospectively recorded and analyzed. Two follow-up visits were performed after 1 to 3 and 5 to 8 years from onset, according to the GBS Disability Scale, and recovery of motor function was assessed during patients’ visits to the clinic. Results: We found 35 male and 36 female subjects with an average age of 6.17 ± 3.82 (range 0.9 up to 15 years old); cases were mostly presented with myalgia and weakness (78.9%) followed by headache, found in 5 patients (7%). Around 84.5% of patients had an upper respiratory infection as their antecedent infection. Fifteen cases of autonomic dysfunction were observed, and 15 patients had cranial nerve involvement. Most cases had the acute inflammatory demyelinating polyradiculoneuropathy (AIDP) form of GBS on electrophysiologic tests. Analysis showed only axonal involvement was significantly correlated with poor prognosis (P-value

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儿童格林-巴-罗综合征的临床表现及预后的回顾性单中心研究

背景:吉兰-巴勒综合征(GBS)是一种感染后免疫介导的周围神经病变，通常以双侧对称进展，影响感觉和运动功能。大多数病例完全康复，但约20%的病例可能导致并发症、不完全康复甚至死亡。目的:本研究旨在评估小儿GBS患者的预后以及可能与恢复或预后相关的条件。方法:对2014年3月至2017年3月在Mofid儿科医院住院的71例GBS进行调查。回顾性记录和分析人口统计学、临床和实验室数据。根据GBS残疾量表，在发病1 ~ 3年和5 ~ 8年后进行两次随访，并在患者就诊期间评估运动功能的恢复情况。结果:男性35例，女性36例，平均年龄6.17±3.82岁(0.9 ~ 15岁);主要表现为肌痛和虚弱(78.9%)，其次为头痛(5例，7%)。约84.5%的患者既往感染为上呼吸道感染。观察自主神经功能障碍15例，其中颅神经受累15例。电生理检查显示，大多数病例为急性炎症性脱髓鞘性多根神经病变(AIDP)型GBS。分析显示，仅轴突受累与预后不良显著相关(p值

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来源期刊

Iranian Journal of Pediatrics 医学-小儿科

CiteScore

0.90

自引率

20.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Iranian Journal of Pediatrics (Iran J Pediatr) is a peer-reviewed medical publication. The purpose of Iran J Pediatr is to increase knowledge, stimulate research in all fields of Pediatrics, and promote better management of pediatric patients. To achieve the goals, the journal publishes basic, biomedical, and clinical investigations on prevalent diseases relevant to pediatrics. The acceptance criteria for all papers are the quality and originality of the research and their significance to our readership. Except where otherwise stated, manuscripts are peer-reviewed by minimum three anonymous reviewers. The Editorial Board reserves the right to refuse any material for publication and advises that authors should retain copies of submitted manuscripts and correspondence as the material cannot be returned. Final acceptance or rejection rests with the Editors.