Functional Abnormalities in the Hippocampus and Impaired Hippocampal‐dependent Learning in Mice Lacking the 5HT1A Receptors

Abstract

KO animals showedimpairments in hippocampal-dependent learning and memory tests, such as the hiddenplatform (spatial) version of the Morris water maze (MWM) and the delayed version ofY-maze. Performance of KO mice was not impaired in non-hippocampal memory taskssuch as the visible platform (non-spatial) version of the MWM, the immediate version ofthe Y-maze, and the spontaneous alternation test of working memory. These resultsdemonstrate that 5HT