Design and automation of an electrospinning system to prepare micro and nanofibers. Case study: elaboration of polymeric micro and nanofibers for vaginal drug delivery

IF 1.3 4区 计算机科学 Q1 Computer Science
Beatriz Martínez-Pérez, Ana Daniela OLIVANO-ESQUIVEL, Jorge FERNÁNDEZ-RETANA, Gustavo Vidal-Romero
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引用次数: 0

Abstract

In the present investigation was optimized and automated a prototype of an electrospinning system. In addition, the methodology for preparing the polymeric film with polycaprolactone micro and nanofibers (PCL) loaded with Neem extract was optimized as a proposal for the treatment of cervical cancer. Also, a UV-VIS spectrophotometric method was developed for the quantification of Neem extract encapsulated in PCL polymeric nanofibers through the formation of a colorimetric complex with FeCl3. The wavelength used to quantify the Neem extract was 423 nm. The prototype built allowed the formation of nanofibers loaded with Neem extract with a diameter of 22-71 nm in diameter. The encapsulation efficiency of the Neem extract was 78.4%.
微纳米纤维静电纺丝系统的设计与自动化。案例研究:用于阴道给药的聚合物微纤维和纳米纤维的精加工
本研究对静电纺丝系统的原型进行了优化和自动化。此外,优化了负载印楝提取物的聚己内酯微纳米纤维(PCL)聚合物膜的制备方法,为宫颈癌的治疗提出了建议。同时,建立了一种紫外可见分光光度法,通过与FeCl3形成比色络合物来定量包裹在PCL聚合物纳米纤维中的印楝提取物。测定印楝提取物的波长为423 nm。构建的原型允许形成纳米纤维,其中装载了直径为22-71纳米的印楝提取物。印楝提取物包封率为78.4%。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IBM Journal of Research and Development
IBM Journal of Research and Development 工程技术-计算机:硬件
自引率
0.00%
发文量
0
审稿时长
6-12 weeks
期刊介绍: The IBM Journal of Research and Development is a peer-reviewed technical journal, published bimonthly, which features the work of authors in the science, technology and engineering of information systems. Papers are written for the worldwide scientific research and development community and knowledgeable professionals. Submitted papers are welcome from the IBM technical community and from non-IBM authors on topics relevant to the scientific and technical content of the Journal.
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