Review paper The role of extracellular matrix metalloproteinases and their inhibitors in allergic diseases

A. Kuźmiński, M. Przybyszewski, M. Graczyk, Z. Bartuzi
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引用次数: 6

Abstract

During the migration to the site of inflammation, allergic inflammatory cells must overcome several structures that constitute an impregnable barrier under normal conditions. One such structure is the extracellular matrix respon sible for closely filling the intercellular space of tissues. The loosening of this tight structure by the activity of spe cific tissue enzymes, i.e. extracellular matrix metalloproteinases (MMPs), enables the influx of effector cells to the site of inflammation, thus facilitating the development of allergic inflammation and sustaining its presence. Specific tissue inhibitors of metalloproteinases (TIMPs) represent the most important factor involved in the regu lation of MMP activity. Under physiological conditions, MMPs and TIMPs co-exist in a particular specific equilibri um, which is disturbed under pathological circumstances. The MMP-2 and MMP-9, referred to as gelatinases, belong to the best-studied MMPs associated with the development of allergic disorders. Their role pertains to the degra dation of type IV collagen, the main component of basal membranes; this facilitates the influx of cells to the site of allergic inflammation.
细胞外基质金属蛋白酶及其抑制剂在变应性疾病中的作用
在迁移到炎症部位的过程中,过敏性炎症细胞必须克服几个结构,这些结构在正常情况下构成了一个坚不可摧的屏障。其中一种结构是细胞外基质,负责紧密填充组织的细胞间隙。特定组织酶(即细胞外基质金属蛋白酶(MMPs))的活性使这种紧密结构松动,使效应细胞涌入炎症部位,从而促进过敏性炎症的发展并维持其存在。金属蛋白酶的特异性组织抑制剂(TIMPs)是调控金属蛋白酶活性的最重要因素。在生理条件下,MMPs和TIMPs以一种特定的平衡共存,在病理条件下,这种平衡被扰乱。被称为明胶酶的MMP-2和MMP-9属于研究得最好的与过敏性疾病发展相关的MMPs。它们的作用与IV型胶原蛋白(基底膜的主要成分)的降解有关;这有利于细胞涌入过敏性炎症部位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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