Phenolic Composition, Antioxidant and Antimicrobial Activity of Cotoneaster Medik. Species from Bosnia and Herzegovina

IF 0.2 Q4 CHEMISTRY, MULTIDISCIPLINARY

Glasnik Hemicara i Tehnologa Bosne i Hercegovine Pub Date : 2020-06-30 DOI:10.35666/ghtbbh.2020.54.01

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引用次数: 2

Abstract

Although the genus Cotoneaster Medik. includes mainly ornamental species, there are some data regarding its biological activity. The purpose of this study was to analyze the content of phenolic compounds, acetylcholinesterase inhibition, antioxidant and antimicrobial activity of methanolic extracts of leaf and bark of C. integerrimus Medik., C. tomentosus (Aiton) Lindl. and C. horizontalis Decne. The C. tomentosus leaf extract exhibited the highest content of total phenols (135.86 mg GAE/g) and flavonoids (18.17 mgQE/g), and also the most potent antioxidant activity against nonbiogenic free radicals, while the highest inhibition of acetylcholinesterase had the leaf extract of C. horizontalis (IC50 0.34 mg/mL). All extracts showed a significant level of antibacterial and antifungal activity against tested microbial strains. The largest inhibition zones were observed against Candida albicans treated with C. integerrimus leaf extract (30.50±0.50 mm). Furthermore, C. integerrimus extract was the most effective in the majority of bacterial strains tested. The results indicated that methanolic extracts of the investigated Cotoneaster species have promising bioactive and therapeutic potentials

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红棉提取物的酚类成分及其抗氧化和抗菌活性。来自波斯尼亚和黑塞哥维那的物种

虽然棉花属。主要包括观赏植物，有一些关于其生物活性的资料。摘要本研究旨在分析荆芥叶和树皮甲醇提取物的酚类化合物含量、乙酰胆碱酯酶抑制作用、抗氧化和抗菌活性。， C. tomentosus (Aiton);C. horizontalis Decne。毛毛藤叶提取物总酚含量最高(135.86 mg GAE/g)，总黄酮含量最高(18.17 mgQE/g)，抗非生物源性自由基活性最强，对乙酰胆碱酯酶的抑制作用最强(IC50为0.34 mg/mL)。所有提取物均显示出显著水平的抑菌和抗真菌活性。纯葡萄叶提取物对白色念珠菌的抑制区最大(30.50±0.50 mm);此外，在大多数测试的细菌菌株中，纯葡萄球菌提取物是最有效的。结果表明，该植物的甲醇提取物具有良好的生物活性和治疗潜力

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Glasnik Hemicara i Tehnologa Bosne i Hercegovine CHEMISTRY, MULTIDISCIPLINARY-

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