Clarification of the irritating and toxic effects of bentonite-like clays

A. Vezentsev, V. Bukhanov, A. Lopanov, N. Zuev, U. Krut, G. Shaidorova
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Abstract

This article studies the action and biocompatibility of the developed montmorillonite-containing preparation “Sorbent” on experimental animals with its longterm use. The local irritating effect of the “Sorbent” preparation was evaluated by its effect on the gastric mucosa of animals with experimental ulcerative pathology. The size of the most common particles in the suspension is 5-8 microns. The experiments were carried out on white rats of the Wistar line and non-linear Hartley guinea pigs. To identify the irritating effect, the drug was administered to animals in therapeutic doses of 200 mg/kg and three times the conditionally therapeutic dose 600 mg/kg of body weight. Destructive changes in the stomachs of experimental animals were studied macroscopically. The ulcerogenic effect was evaluated by calculating the Pauls index. Keywords—enterosorbent, montmorillonite, ulcerative pathology, inflammatory process
澄清类膨润土粘土的刺激性和毒性作用
本文研究了研制的含蒙脱石制剂“吸附剂”在实验动物上的作用和生物相容性,并对其进行了长期使用。通过对实验性溃疡病理动物胃粘膜的影响来评价“吸附剂”制剂的局部刺激作用。悬浮液中最常见的颗粒大小为5-8微米。实验用Wistar系大鼠和非线性哈特利豚鼠进行。为了确定刺激作用,以200 mg/kg的治疗剂量和3倍于600 mg/kg体重的条件治疗剂量给药动物。从宏观上研究了实验动物胃的破坏性变化。通过计算paul指数评价其致溃疡作用。关键词:肠吸收剂,蒙脱石,溃疡病理,炎症过程
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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