Are Altered Expression of Vascular Endothelial Growth Factor and Placental Growth Factor Associated with Placental Angiogenesis in Recurrent Pregnancy Loss?

IF 0.8 1区历史学 0 CLASSICS

JOURNAL OF ROMAN STUDIES Pub Date : 2024-07-01 Epub Date: 2023-02-09 DOI:10.1007/s12291-023-01117-4

Shehnaz Sultana, M R Renjini Devi, Mahesh Kumar Rathod, Penagaluru Pardhanandana Reddy, Venkateshwari Ananthapur

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引用次数: 0

Abstract

Angiogenesis is one of the most important steps during pregnancy for placental and fetal development. Based on the hypothesis that vascular insufficiency and altered angiogenesis may lead to early pregnancy loss, the present study was aimed to understand the role of Vascular endothelial growth factor (VEGFA) and Placental growth factor (PLGF) gene expression in placental angiogenesis in the pathogenesis of Recurrent pregnancy loss (RPL). Gene expression analysis of VEGFA and PLGF was carried out in the placental tissue collected from 30 women with recurrent pregnancy loss and compared with the placenta obtained from 16 women with medically terminated pregnancy. The mRNA expression of both VEGFA and PLGF genes were significantly downregulated in the placenta of recurrent pregnancy loss in comparison to the placenta of medically terminated pregnancies. In conclusion the results of the present study suggest that altered expression of VEGFA and PLGF genes in placenta disturb the angiogenesis and contribute to the pathogenesis of recurrent pregnancy loss.

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血管内皮生长因子和胎盘生长因子的表达改变与复发性妊娠失败中的胎盘血管生成有关吗？

血管生成是孕期胎盘和胎儿发育最重要的步骤之一。基于血管功能不全和血管生成改变可能导致早期妊娠失败的假设，本研究旨在了解血管内皮生长因子（VEGFA）和胎盘生长因子（PLGF）基因表达在胎盘血管生成中的作用，以及复发性妊娠失败（RPL）的发病机制。研究人员对 30 名复发性妊娠丢失妇女的胎盘组织进行了血管内皮生长因子（VEGFA）和胎盘生长因子（PLGF）基因表达分析，并与 16 名药物终止妊娠妇女的胎盘进行了比较。与药物终止妊娠的胎盘相比，复发性妊娠流产的胎盘中 VEGFA 和 PLGF 基因的 mRNA 表达均显著下调。总之，本研究结果表明，胎盘中VEGFA和PLGF基因表达的改变会干扰血管生成，并导致复发性妊娠失败的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

JOURNAL OF ROMAN STUDIES CLASSICS-

CiteScore

1.10

自引率

22.20%

发文量

期刊介绍： The Journal of Roman Studies (JRS) has appeared annually for a century, and is widely recognised as the premier UK journal in its field. Peer-reviewed papers on Roman history and Latin literature form the larger part of each issue. Papers on art history and archaeology are also published. The Journal regularly includes major review articles and archaeological surveys, along with one of the widest selections of reviews of recent publications in all scholarly languages. The journal seeks to publish articles with wide implications for our understanding of the Roman world. JRS papers have stimulated debates in fields as diverse as Roman democracy, the scale of the Roman economy, the demographic implications of slavery, and the materiality of the book.