{"title":"Carcinosarcoma of the parotid gland: Immunohistochemical analysis with emphasis in cell cycle mitotic activity and cell adhesion molecules expression","authors":"Dimitrios Andreadis , Athanasios Poulopoulos , Apostolos Epivatianos , Alexandros Nomikos , Konstantinos Christidis , Calypso Barbatis","doi":"10.1016/j.ooe.2005.10.004","DOIUrl":null,"url":null,"abstract":"<div><p>Carcinosarcoma is a rare salivary gland neoplasm consisting of both carcinomatous and sarcomatous component. It may arises de novo or on a pre-existing pleomorphic adenoma. We present a case of parotid carcinosarcoma, exhibiting features of salivary ductal adenocarcinoma (carcinomatous element) and fibrosarcoma/osteosarcoma (sarcomatous element). Immunohistochemical analysis with Ki67, p53, p27, C-KIT, bcl2, cerbB2, SMA, VIM has performed and cell adhesion molecules’ expression, E-cadherin, beta4-integrin, desmoglein-2, CD44s and ICAM-1 has been detected. In conclusion carcinosarcoma is an aggressive tumor, with a biphasic malignant neoplastic component showing characteristic immunohistochemical profile and reduced or extremely alternative CAMs expression.</p></div>","PeriodicalId":100990,"journal":{"name":"Oral Oncology Extra","volume":"42 4","pages":"Pages 140-143"},"PeriodicalIF":0.0000,"publicationDate":"2006-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ooe.2005.10.004","citationCount":"5","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Oral Oncology Extra","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1741940905000993","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 5
Abstract
Carcinosarcoma is a rare salivary gland neoplasm consisting of both carcinomatous and sarcomatous component. It may arises de novo or on a pre-existing pleomorphic adenoma. We present a case of parotid carcinosarcoma, exhibiting features of salivary ductal adenocarcinoma (carcinomatous element) and fibrosarcoma/osteosarcoma (sarcomatous element). Immunohistochemical analysis with Ki67, p53, p27, C-KIT, bcl2, cerbB2, SMA, VIM has performed and cell adhesion molecules’ expression, E-cadherin, beta4-integrin, desmoglein-2, CD44s and ICAM-1 has been detected. In conclusion carcinosarcoma is an aggressive tumor, with a biphasic malignant neoplastic component showing characteristic immunohistochemical profile and reduced or extremely alternative CAMs expression.
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