Review of antidepressants in the treatment of behavioral and psychiatric symptoms in dementia (BPSD)

Whitney M. Buterbaugh, Todd Jamrose, J. Lazzara, L. Honaker, Christopher J Thomas
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引用次数: 6

Abstract

Behavioral disturbances are commonplace among patients with dementia. Management of these symptoms has proved difficult.1,2 Currently, there are no FDA approved pharmacologic treatments for the treatment of BPSD.3 Traditionally, atypical antipsychotics have been used to treat behavioral disturbances despite modest efficacy and undesirable adverse effects.3,4,5 Because of the increase in mortality, there is a continued push to reduce antipsychotic utilization in this population.9,10 Thus, many clinicians are using alternative agents such as antidepressants and mood stabilizers to help treat BPSD, while avoiding using antipsychotics. The goal of this review is to review, analyze, and discuss the current literature available on the use of antidepressants to treat BPSD.
抗抑郁药物治疗痴呆(BPSD)行为和精神症状的研究进展
行为障碍在痴呆症患者中很常见。这些症状的处理已证明是困难的。目前,FDA还没有批准用于治疗bpsd的药物治疗方法。传统上,非典型抗精神病药物已被用于治疗行为障碍,尽管疗效适度且有不良反应。3,4,5由于死亡率的增加,在这一人群中不断有减少抗精神病药物使用的呼声。9,10因此,许多临床医生使用抗抑郁药和情绪稳定剂等替代药物来帮助治疗BPSD,同时避免使用抗精神病药物。本综述的目的是回顾、分析和讨论目前可用的关于使用抗抑郁药治疗BPSD的文献。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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