A POOLED META-ANALYSIS; THE ROLE OF GENETIC AND ENVIRONMENT ON THE INCIDENCE OF PESTICIDES INTOXICATION ON WORKERS

Ela Laelasari, H. Kusnoputranto, B. Budiawan
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Abstract

The use of pesticides for pest repellent can trigger the risk of cancer and degenerative diseases for certain groups. The interaction of genetic and environmental (GxE) to be crucial for the case of pesticide intoxication. Knowing the role of genetic factors could be a way of preventing the incidence of intoxication from harmful chemicals pesticides through meta-analysis studies explore the differences between the groups of workers who are at risk with resesive alleles and non-alleles resesive. Statistically significant difference was found in the value of the odds ratio (OR) of 1.6 (CI 0.99-1.02) Keywords: Pesticide; biotransformation; genetic; environment
荟萃分析;遗传和环境对工人农药中毒发生率的影响
使用杀虫剂驱虫会引发某些人群患癌症和退行性疾病的风险。遗传和环境的相互作用(GxE)是农药中毒的关键情况下。了解遗传因素的作用可能是预防有害化学物质农药中毒的一种方法,通过荟萃分析研究探索具有抗性等位基因和非等位基因抗性的工人群体之间的差异。比值比(OR)为1.6,差异有统计学意义(CI 0.99 ~ 1.02);生物转化;基因;环境
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