Discontinuing Disease-Modifying Therapies in Nonactive Secondary Progressive MS: Review of the Evidence

Natasha Antonovich
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引用次数: 1

Abstract

Background: There are currently no disease-modifying therapies (DMTs) on the market approved for nonactive secondary progressive multiple sclerosis (SPMS), and lifelong DMTs are neither indicated nor supported by evidence. Nevertheless, the discontinuation of DMTs has been a long-debated topic with varied opinions on how and when to discontinue. Observations: This article reviews the current literature regarding the discontinuation of DMTs in nonactive SPMS. Discontinuing DMTs does not seem to have deleterious effects on the nonactive SPMS disease course and may improve quality of life. Conclusions: The growing evidence in this area may make discontinuation of DMTs in nonactive SPMS a less debatable topic, but it is still a major treatment decision that clinicians must thoroughly discuss with the patient to provide high-quality, patient-centered care.
停止治疗非活动性继发性进展性MS:证据回顾
背景:目前市场上还没有批准用于非活动性继发性进行性多发性硬化症(SPMS)的疾病修饰疗法(dmt),并且终身dmt既没有指征也没有证据支持。然而,dmt的停止一直是一个长期争论的话题,关于如何以及何时停止有不同的意见。观察:本文回顾了目前关于非活性SPMS患者停用dmt的文献。停用dmt似乎不会对非活动性SPMS病程产生有害影响,并可能改善生活质量。结论:该领域越来越多的证据可能会使非活动性SPMS患者停用dmt成为一个较少争议的话题,但它仍然是一个主要的治疗决策,临床医生必须与患者充分讨论,以提供高质量的、以患者为中心的护理。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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