Antibacterial effects study of nanofluid containing carbon nanotubes and evaluation of its efficacy on reducing antibiotic resistance of Pseudomonas aeruginosa

Abstract

Background: Pseudomonas aeruginosa is an opportunistic gram-negative bacterium that causes infections of the urinary tract, respiratory tract, skin inflammation, soft tissue infections, and a variety of systemic infections. Increased antibiotic resistance in Pseudomonas aeruginosa has led to its introduction as one of the most important nosocomial infections. Recently, carbon nanotubes are important and effective antibacterial agents. Materials and methods: Carbon nanotubes were prepared as carboxyl-functionalized nanofluids and then were evaluated on Pseudomonas aeruginosa to reduce antibiotic resistance. Results: It was observed that multi-walled carbon nanotubes had antimicrobial effects on Pseudomonas aeruginosa. Bacterial resistance to the antibiotic meropenem was also significantly reduced in the presence of nanofluids containing functionalized carbon nanotubes. Thus, by co-administration of functionalized carbon nanotubes and meropenem, in the nanofluid condition, a significant reduction in growth was observed. Conclusion: In the present study, using nanofluids containing functionalized carbon nanotubes and also increasing its stability, the antibiotic resistance of Pseudomonas aeruginosa was significantly reduced in lower dilutions than antibiotics alone. However, more specialized cellular and molecular research are needed to obtain more accurate results.