The role of diffusion-weighted MRI in characterization of intracranial cystic lesions

Ghada Kohla, Emam AbdelAziz, H. Abd-Elwahab
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Abstract

Background Diffusion-weighted imaging (DWI) is reliable in diagnosing intracranial cysts. However, sometimes, it could not give satisfactory diagnostic confidence. Objective To study the role of DWI in differentiation between intracranial cysts and the usefulness of apparent diffusion coefficient. Patients and methods This study included 40 patients of different age groups with intracranial cysts. All patients included were subjected to full history taking, clinical examination, laboratory investigations, routine MRI examination, DWI, and apparent diffusion coefficient map. Results Receiver operating characteristic curve was generated to identify inflammatory intra-axial lesions and to obtain the best sensitivity (80%), specificity (83.3%), positive predictive value (80%), and negative predictive value (83.3%). The relationship was significant (P<0.028). Receiver operating characteristic curve to identify epidermoid and arachnoid cysts and to obtain the best sensitivity (100%), specificity (100%), positive predictive value (100%), and negative predictive value (100%). The relationship was significant (P=0.013). Conclusion DWI is perfect in differentiating between necrotic tumors and abscesses, benign and malignant intracranial cysts, and between arachnoid and epidermoid cysts. But it failed in differentiating between lower-grade and high-grade glioma.
磁共振弥散加权成像在颅内囊性病变诊断中的作用
背景弥散加权成像(DWI)对颅内囊肿的诊断是可靠的。然而,有时它不能给出令人满意的诊断信心。目的探讨DWI在颅内囊肿鉴别中的作用及视弥散系数的应用价值。患者与方法本研究包括40例不同年龄组颅内囊肿患者。所有纳入的患者均接受了完整的病史、临床检查、实验室检查、常规MRI检查、DWI检查和表观弥散系数图。结果生成受试者工作特征曲线,识别轴内炎性病变,获得最佳敏感性(80%)、特异性(83.3%)、阳性预测值(80%)和阴性预测值(83.3%)。相关性显著(P<0.028)。采用受试者工作特征曲线识别表皮样囊肿和蛛网膜囊肿,获得最佳敏感性(100%)、特异性(100%)、阳性预测值(100%)和阴性预测值(100%)。相关性显著(P=0.013)。结论DWI对坏死性肿瘤与脓肿、颅内囊肿良恶性、蛛网膜囊肿与表皮样囊肿具有较好的鉴别价值。但它无法区分低级和高级胶质瘤。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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