Roadmap on nanomedicine for the central nervous system

IF 2.9 4区物理与天体物理 Q2 OPTICS

Journal of Nonlinear Optical Physics & Materials Pub Date : 2022-12-14 DOI:10.1088/2515-7639/acab88

G. Ciofani, M. Campisi, C. Mattu, R. Kamm, V. Chiono, A. M. Raynold, J. S. Freitas, Eugenio Redolfi Riva, S. Micera, C. Pucci, F. Novio, J. Lorenzo, D. Ruíz-Molina, Giulia Sierri, F. Re, Hannah Wunderlich, Prachi Kumari, K. Kozielski, Mounia Chami, Attilio Marino, Lino Ferreira

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引用次数: 1

Abstract

In recent years, a great deal of effort has been undertaken with regards to treatment of pathologies at the level of the central nervous system (CNS). Here, the presence of the blood-brain barrier acts as an obstacle to the delivery of potentially effective drugs and makes accessibility to, and treatment of, the CNS one of the most significant challenges in medicine. In this Roadmap article, we present the status of the timeliest developments in the field, and identify the outstanding challenges and opportunities that exist. The format of the Roadmap, whereby experts in each discipline share their viewpoint and present their vision, reflects the dynamic and multidisciplinary nature of this research area, and is intended to generate dialogue and collaboration across traditional subject areas. It is stressed here that this article is not intended to act as a comprehensive review article, but rather an up-to-date and forward-looking summary of research methodologies pertaining to the treatment of pathologies at the level of the CNS.

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中枢神经系统纳米医学路线图

近年来，在中枢神经系统(CNS)水平的病理治疗方面进行了大量的努力。在这里，血脑屏障的存在阻碍了潜在有效药物的输送，使中枢神经系统的可及性和治疗成为医学上最重大的挑战之一。在这篇路线图文章中，我们介绍了该领域最及时的发展现状，并确定了存在的突出挑战和机遇。路线图的格式反映了该研究领域的动态和多学科性质，旨在促进传统学科领域之间的对话和合作，每个学科的专家借此分享他们的观点并提出他们的愿景。这里要强调的是，这篇文章不打算作为一个全面的评论文章，而是一个最新的和前瞻性的研究方法的总结与病理治疗在中枢神经系统的水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Nonlinear Optical Physics & Materials 物理-光学

CiteScore

3.00

自引率

48.10%

发文量

审稿时长

3 months

期刊介绍： This journal is devoted to the rapidly advancing research and development in the field of nonlinear interactions of light with matter. Topics of interest include, but are not limited to, nonlinear optical materials, metamaterials and plasmonics, nano-photonic structures, stimulated scatterings, harmonic generations, wave mixing, real time holography, guided waves and solitons, bistabilities, instabilities and nonlinear dynamics, and their applications in laser and coherent lightwave amplification, guiding, switching, modulation, communication and information processing. Original papers, comprehensive reviews and rapid communications reporting original theories and observations are sought for in these and related areas. This journal will also publish proceedings of important international meetings and workshops. It is intended for graduate students, scientists and researchers in academic, industrial and government research institutions.