Deep Brain Stimulation or Pallidotomy for Dystonia in Neurodegeneration with Brain Iron Accumulation? A Call for Justice To the Balance

Abstract

Neurodegeneration with brain iron accumulation (NBIA) comprises a group of rare but devastating inherited neurological diseases with unifying features of gradual cognitive and motor decline, and progressive degeneration of basal ganglia, globus pallidus, and reticular part of substantia nigra, produced by brain iron accumulation [1]. The most common disorders presented in infancy and childhood are Betapropeller Protein‐Associated Neurodegeneration, Pantothenate Kinase‐ Associated Neurodegeneration, PhosphoLipase A2‐Associated Neurodegeneration, and Mitochondrial membrane Protein‐ Associated Neurodegeneration [2].