Study on Cytomorphology of Solid Pseudopapillary Tumor (SPT) in pancreas and its Differential Diagnosis

Abstract

The solid pseudopapillary tumor is a rare pancreatic neoplasm with many pseudonyms of uncertain to low malignant potential and predominant in young women under the age group of 20-36 years. This study was aimed to study of four such cases diagnosed on fine needle aspiration cytology (FNAC) in 2021-22 and its correlation with cytohistology. The image-guided FNAS was performed in these four patients prior to operation and later cytomorphological findings were evaluated by alcohol-fixed smears stained with Papanicolaou stain and diagnosis were made. Diagnosis were later confirmed by histology in the study which showed characteristic cytological features such as hypercellular smears with presence of abundant delicate papillary fragments, non-cohesive cells, heterogenic tumor cells with delicate folded nuclear membranes, and foamy macrophages in the background. Preoperative correct diagnosis of solid pseudopapillary tumor of pancreas is possible on FNAC and by doing so it helps in management of this surgically curable neoplasm.