Association analysis of APOA5 rs662799 and rs3135506 polymorphisms with obesity in Moroccan patients

Pathologie-biologie Pub Date : 2015-12-01 DOI:10.1016/j.patbio.2015.09.002

F. Lakbakbi el Yaagoubi , H. Charoute , A. Bakhchane , M. Ajjemami , H. Benrahma , A. Errouagui , M. Kandil , H. Rouba , A. Barakat

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引用次数: 6

Abstract

The aim of the present study is to explore the association between the APOA5 polymorphisms and haplotypes with obesity in Moroccan patients. The study was performed in 459 subjects, Obese (n = 164) and non-obese (n = 295). All subjects were genotyped for the APOA5 -1131T > C (rs662799) and c.56C > G (rs3135506) polymorphisms. The contribution of APOA5 polymorphisms and haplotypes in the increased risk of obesity were explored using logistic regression analyses. The -1131T > C and c.56C > G polymorphisms were significantly associated with obesity. Both polymorphisms were strongly associated with increased BMI. Analysis of constructed haplotypes showed a significant association between CG haplotype and susceptibility to obesity (OR [95%CI] = 3.09 [1.93–4.97]; P < 0.001). These results support a potential role for APOA5 common variants and related haplotypes as risk factors for obesity.

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摩洛哥APOA5 rs662799和rs3135506多态性与肥胖的关联分析

本研究的目的是探讨APOA5多态性和单倍型与摩洛哥患者肥胖之间的关系。该研究在459名受试者中进行，肥胖(n = 164)和非肥胖(n = 295)。所有受试者均为APOA5 -1131T基因分型;C (rs662799)和C . 56c >G (rs3135506)多态性。利用logistic回归分析探讨APOA5多态性和单倍型在肥胖风险增加中的作用。-1131T >C和C .56C >G多态性与肥胖显著相关。这两种多态性都与BMI增加密切相关。构建的单倍型分析显示，CG单倍型与肥胖易感性之间存在显著相关性(OR [95%CI] = 3.09 [1.93-4.97];P & lt;0.001)。这些结果支持APOA5常见变异和相关单倍型作为肥胖危险因素的潜在作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pathologie-biologie 医学-病理学

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0.00%

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审稿时长

6-12 weeks