Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin

IF 0.9 4区工程技术 Q3 Engineering

Quantum Electronics Pub Date : 2022-01-01 DOI:10.1070/QEL17966

I. Shilov, A. S. Gorshkova, A. Ivanov, V. Rumyantseva, G. Danielyan, V. Kashin

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引用次数: 0

Abstract

We report the results of developing a technique for theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy (PDT) in the absorption band of porphyrin. It is shown that the therapeutic effect is achieved exclusively due to PDT, without the participation of the hyperthermia process, which occurs at temperatures above 42°C. The Fluroscan gel [based on the dipotassium salt of the ytterbium complex of 2,4-di-(α-methoxyethyl)deuteroporphyrin IX (Yb-DMDP)] is used as a preparation for theranostics. The main photophysical properties and possible mechanisms of accumulation of nanosized low-toxic photosensitisers based on this compound are studied. It is shown that the Yb-DMDP compound in a DMSO solution (30 % aqueous DMSO) enhances photophysical characteristics (luminescence lifetime 5 – 10 μs, luminescence quantum yield up to 1 %, extinction coefficient ∼1.96 × 105 M−1 cm−1 at a wavelength of 398 nm). Experimental animals are used to test the proposed technique for theranostics of tumours using the Fluroscan gel and a fibre-optic laser fluorimeter.

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基于荧光诊断结合卟啉吸收带光动力治疗的皮肤肿瘤治疗

我们报告了一种基于荧光诊断结合卟啉吸收带光动力治疗(PDT)的皮肤肿瘤治疗技术的研究结果。研究表明，治疗效果完全是由于PDT而实现的，而不需要热疗过程的参与，热疗过程发生在42℃以上的温度下。Fluroscan凝胶[基于2,4-二-(α-甲氧基乙基)重卟啉IX (Yb-DMDP)的镱络合物的二钾盐]被用作治疗制剂。研究了该化合物制备纳米级低毒光敏剂的主要光物理性质和可能的蓄积机理。结果表明，Yb-DMDP化合物在DMSO溶液(30% DMSO水溶液)中增强了光物理特性(发光寿命5 ~ 10 μs，发光量子产率高达1%，消光系数~ 1.96 × 105 M−1 cm−1，波长为398 nm)。实验动物被用来测试使用Fluroscan凝胶和光纤激光荧光计的肿瘤治疗技术。

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来源期刊

Quantum Electronics 工程技术-工程：电子与电气

CiteScore

3.00

自引率

11.10%

发文量

审稿时长

3-6 weeks

期刊介绍： Quantum Electronics covers the following principal headings Letters Lasers Active Media Interaction of Laser Radiation with Matter Laser Plasma Nonlinear Optical Phenomena Nanotechnologies Quantum Electronic Devices Optical Processing of Information Fiber and Integrated Optics Laser Applications in Technology and Metrology, Biology and Medicine.