Tale of the unseen phage

Bacteriophage Pub Date : 2013-07-11 DOI:10.4161/bact.25985
J. Mahony, S. Ainsworth, D. van Sinderen
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引用次数: 1

Abstract

Lactococcal phages are among the best characterized phages of Gram-positive bacteria and as such represent excellent models to promote our understanding of phage-host interactions. In recent years, microarray technology has been employed to define the transcriptional profile of phages during infection, while simultaneously uncovering the response of the host to the infection event. The responses to infection by a lytic and a temperate phage of Lactococcus lactis were analyzed, combined with an assessment of the host response to lysogenisation with the temperate phage, Tuc2009. Here, we discuss the lessons learned from such transcriptional profiling studies, focusing on studies relating to phages of Lactococcus lactis, and how this knowledge may be applied to future studies.
看不见的噬菌体的故事
乳球菌噬菌体是革兰氏阳性菌中最具特征的噬菌体之一,因此代表了促进我们对噬菌体-宿主相互作用的理解的优秀模型。近年来,微阵列技术已被用于确定噬菌体在感染过程中的转录谱,同时揭示宿主对感染事件的反应。分析了乳酸乳球菌裂解噬菌体和温和噬菌体对感染的反应,并评估了宿主对温和噬菌体溶原作用的反应,Tuc2009。在这里,我们讨论了从这些转录谱研究中吸取的教训,重点是与乳酸乳球菌噬菌体有关的研究,以及如何将这些知识应用于未来的研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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