Isolated branched-chain amino acid intake and muscle protein synthesis in humans: a biochemical review.

IF 3.4 2区社会学 Q1 LAW

Columbia Law Review Pub Date : 2019-09-05 DOI:10.31744/einstein_journal/2019RB4898

Carina de Sousa Santos, Fabrício Expedito Lopes Nascimento

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Abstract

Alongside a proper diet, ergogenic aids with potential direct and/or indirect physical performance enhancing effects are sought after for improved adaptation to physical training. Nutritional ergogenics include diet composition changes and/or dietary supplementation. Branched-chain amino acids valine, leucine and isoleucine are widely popular among products with ergogenic claims. Their major marketing appeal derives from allegations that branched-chain amino acids intake combined with resistance physical exercise stimulates muscle protein synthesis. Evidence supporting the efficacy of branched-chain amino acids alone for muscle hypertrophy in humans is somewhat equivocal. This brief review describes physiological and biochemical mechanisms underpinning the effects of complete protein source and branched-chain amino acid intake on skeletal muscle growth in the postabsorptive and post-exercise state. Evidence in favor of or against potential anabolic effects of isolated branched-chain amino acid intake on muscle protein synthesis in humans is also examined.

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人的分离支链氨基酸摄入量和肌肉蛋白质合成：生化综述。

除了合理膳食外，人们还寻求具有潜在直接和/或间接提高体能效果的促效剂，以改善对体育训练的适应。营养增效剂包括改变饮食成分和/或补充膳食。支链氨基酸中的缬氨酸、亮氨酸和异亮氨酸在声称能增强体质的产品中广受欢迎。它们的主要市场吸引力来自于支链氨基酸摄入量与阻力运动相结合可刺激肌肉蛋白质合成的说法。支持单独使用支链氨基酸促进人体肌肉肥大的证据并不明确。这篇简短的综述描述了在吸收后和运动后状态下，全蛋白质来源和支链氨基酸摄入对骨骼肌生长影响的生理和生化机制。此外，还研究了支持或反对摄入单独支链氨基酸对人体肌肉蛋白质合成产生潜在同化作用的证据。

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来源期刊

Columbia Law Review LAW-

CiteScore

3.00

自引率

6.90%

发文量

期刊介绍： The Columbia Law Review is one of the world"s leading publications of legal scholarship. Founded in 1901, the Review is an independent nonprofit corporation that produces a law journal edited and published entirely by students at Columbia Law School. It is one of a handful of student-edited law journals in the nation that publish eight issues a year. The Review is the third most widely distributed and cited law review in the country. It receives about 2,000 submissions per year and selects approximately 20-25 manuscripts for publication annually, in addition to student Notes. In 2008, the Review expanded its audience with the launch of Sidebar, an online supplement to the Review.