Progress of endoplasmic reticulum stress in chronic obstructive pulmonary disease

Abstract

Endoplasmic reticulum stress (ERS) is an important self-defense mechanism of cells, and strong persistent ERS can induce apoptosis.Unfolded protein reaction is an important signal pathway of ERS.There are many kinds of cell types with high protein synthesis and secretion in lung.It is easy to appear ERS.At present, it is believed that ERS is related to the pathogenesis of chronic obstructive pulmonary disease (COPD). This review focus on the relationship between ERS and COPD, to provide a new direction for the treatment of COPD. Key words: Pulmonary disease, chronic obstructive; Unfolded protein response; Endoplasmic reticulum stress